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The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition,
although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I
allele has its individual rules to which peptides presented in the groove adhere.
Stefan Stevanovié and Günther Jung: Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, W-7400 Tübingen, Germany
Hans-Georg Rammensee: To whom correspondence should be addressed. 290
Max-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, W-7400, Tübingen, Germany
Kirsten Falk, Olaf Rötzschke, Stefan Stevanovié, Günther Jung & Hans-Georg Rammensee
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