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ABSTRACT Clitoral and vaginal engorgement during sexual stimulation depend in part on the increase of arterial inflow. It has been shown that apomorphine (APO), a non-selective dopamine
receptor agonist, produces penile erection by activating dopaminergic receptors in the central nervous system. Our aim was to study whether systemic administration of APO improves the
hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit. Female New Zealand white rabbits (3.5–4 kg, _n_=6) were anesthetized. To examine sexual arousal function, the
vaginal/clitoral branch of the pelvic nerve was stimulated electrically and maximal increases in clitoral intracavernosal and vaginal wall blood flows and pressures were recorded. After this
APO was injected intravenously in a dose–response manner (0.05, 0.1, 0.2, 0.3 and 0.4 mg/kg) and nerve stimulation was performed after each dose. Changes in nerve-stimulated increase of
clitoral intracavernosal and vaginal blood flows and pressures after APO was compared to those recorded before APO. Electrical stimulation of the vaginal/clitoral branch of the pelvic nerve
significantly increased clitoral intracavernosal and vaginal wall blood flows in the rabbit. Intravenous administration of APO caused concentration dependent increase in nerve
stimulation-induced peak clitoral intracavernosal and vaginal wall blood flows reaching to statistically significant at the concentration of 0.1 and 0.2 mg/kg. Inravenous administration of
APO greater than 0.2 mg/kg (0.3 and 0.4 mg/kg) were less effective or produced adverse effects on clitoral intracavernosal and vaginal wall blood flows. Intravenous APO also tended to
increase nerve-stimulated increase of clitoral intracavernosal and vaginal wall pressures, but the effect was not statistically significant. In conclusion, our studies suggest that systemic
administration of APO may improve clitoral and vaginal engorgement by increasing clitoral intracavernosal and vaginal wall arterial inflow. Access through your institution Buy or subscribe
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INHIBITOR IN ELICITING AN ERECTILE RESPONSE IN A RAT MODEL OF RADICAL PROSTATECTOMY Article 20 May 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Urology, Boston University
School of Medicine, Boston, Massachusetts, USA T Tarcan, MB Siroky, I Goldstein & KM Azadzoi * Department of Urology, Chonnam National University Medical School, Kwangju, Korea K Park *
Department of Urology Research, Boston VA Medical Center, Boston, Massachusetts, USA KM Azadzoi Authors * T Tarcan View author publications You can also search for this author inPubMed
Google Scholar * MB Siroky View author publications You can also search for this author inPubMed Google Scholar * K Park View author publications You can also search for this author inPubMed
Google Scholar * I Goldstein View author publications You can also search for this author inPubMed Google Scholar * KM Azadzoi View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tarcan, T., Siroky, M., Park, K. _et al._ Systemic administration of apomorphine
improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit. _Int J Impot Res_ 12, 235–240 (2000). https://doi.org/10.1038/sj.ijir.3900552 Download citation *
Received: 28 February 1999 * Revised: 10 April 2000 * Accepted: 18 May 2000 * Published: 10 October 2000 * Issue Date: August 2000 * DOI: https://doi.org/10.1038/sj.ijir.3900552 SHARE THIS
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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * apomorphine * clitoris * vagina, engorgement * blood flow