Evaluating dose regimens of apomorphine, an open-label study

Evaluating dose regimens of apomorphine, an open-label study

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ABSTRACT The aim of the study was to investigate the safety and efficacy of apomorphine SL (apo SL) 2 and 3 mg, using a dose-optimisation regime in 110 Asian men with erectile dysfunction


(ED) during a 10-week open-label study. Based on daily diaries kept by each patient, 63% showed an improvement in their sexual life. Patient responses to the International Index for Erection


Function 15 questionnaires showed that there was an improvement in erectile function from baseline score after treatment with apo SL (from 15.9 to 20.4), and intercourse satisfaction (from


7.7 to 9.9), as well as slight improvements in orgasmic function (from 6.8 to 7.5) and total satisfaction (from 41.9 to 50.8). There was no marked improvement seen in sexual desire. In


conclusion, apo SL is safe and efficacious in the treatment of ED in this patient population, irrespective of underlying diseases and concomitant medications. Access through your institution


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LOW-DOSE TADALAFIL MAY REDUCE THE PENILE CURVATURE PROGRESSION RATE IN PATIENTS WITH ACUTE PEYRONIE’S DISEASE: A RETROSPECTIVE COMPARATIVE ANALYSIS Article 13 December 2022 REFERENCES *


Thai Erectile Dysfunction Epidemiologic Study Group (TEDES). An epidemiological study of erectile dysfunction in Thailand (Part 1: prevalence). _J Med Assoc Thai_ 2000; 83: 872–879. * Thai


Erectile Dysfunction Epidemiological Study Group. Kongkanand A . Prevalence of erectile dysfunction in Thailand. _Int J Androl_ 2000; 23(Suppl 2): 77–80. Google Scholar  * Von Keitz AT et


al. A European multicentre study to evaluate the tolerability of apomorphine sublingual administered in a forced dose-escalation regimen in patients with erectile dysfunction. _BJU Int_


2002; 89: 409–415. Article  CAS  Google Scholar  * Dula E, et al. Efficacy and safety of fixed-dose and dose-optimization regimens of sublingual apomorphine versus placebo in men with


erectile dysfunction. The Apomorphine Study Group. _Urology_ 2000; 56: 130–135. Article  CAS  Google Scholar  * Rosen RC et al. The international index of erectile function (IIEF): a


multidimensional scale for assessment of erectile dysfunction. _Urology_ 1997; 49: 822–830. Article  CAS  Google Scholar  * Dula E, Bukofzer S, Perdok R, George M . Double-blind, crossover


comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction. _Eur Urol_ 2001; 39: 558–564. Article  CAS  Google Scholar  * Mulhall JP, Bukofzer


S, Edmonds AL, George M . An open-label, uncontrolled dose-optimization study of sublingual apomorphine in erectile dysfunction. _Clin Ther_ 2001; 23: 1260–1271. Article  CAS  Google Scholar


  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Urology, Department of Surgery, Chulalongkorn University Hospital, Bangkok, Thailand A Kongkanand, J Opanuraks


 & K Tantiwongse * Phramongkutklao Hospital, Rajadevi, Bangkok, Thailand N Choeypunt * Department of Surgery, Siriraj Hospital, Faculty of Medicine Siriraj Hospital, Mahidol University,


Bangkok, Thailand A Tantiwong & T Amornvejsukit Authors * A Kongkanand View author publications You can also search for this author inPubMed Google Scholar * J Opanuraks View author


publications You can also search for this author inPubMed Google Scholar * K Tantiwongse View author publications You can also search for this author inPubMed Google Scholar * N Choeypunt


View author publications You can also search for this author inPubMed Google Scholar * A Tantiwong View author publications You can also search for this author inPubMed Google Scholar * T


Amornvejsukit View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Kongkanand. RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kongkanand, A., Opanuraks, J., Tantiwongse, K. _et al._ Evaluating dose regimens of apomorphine, an open-label study. _Int J Impot Res_ 15


(Suppl 2), S10–S12 (2003). https://doi.org/10.1038/sj.ijir.3900992 Download citation * Published: 24 June 2003 * Issue Date: 01 April 2003 * DOI: https://doi.org/10.1038/sj.ijir.3900992


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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * apomorphine SL * efficacy * tolerability * epidemiology