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ABSTRACT _STOYE REPLIES_ — On the basis of analogies between _P_ elements and retroviruses, Langley and Charlesworth suggest that one potential risk associated with xenotransplantation is a
form of insertional mutagenesis resulting from germline integrations by retroviruses derived from endogenous proviruses in the engrafted organs. I agree that these elements are potentially
hazardous, but I am not convinced that the threat posed by this form of genomic bombardmentis great enough to figure significantly in risk-benefit analysis of xenotransplantation. Rather,
the much greater risk is that posed by these elements acting as infectious agents of disease. Access through your institution Buy or subscribe This is a preview of subscription content,
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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Stoye, J. P. _Nature_ 386, 126–127 (1997). Article ADS CAS Google
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Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK Jonathan Stoye Authors * Jonathan Stoye View author publications You can also search for this author inPubMed Google Scholar RIGHTS
AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stoye, J. Endogenous proviruses as “mementos”?. _Nature_ 388, 840 (1997). https://doi.org/10.1038/42172 Download
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