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A drug for treating melanoma is ineffective in colorectal cancers that have the same causative mutation. Studies of how cells adapt to the drug reveal why this is so, and suggest combination
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REFERENCES * Chapman, P. B. et al. _N. Engl. J. Med._ 364, 2507–2516 (2011). Article CAS Google Scholar * Kopetz, S. et al. _J. Clin. Oncol._ 28 (ASCO Meet. Abstr. Pt 1), abstr. 3534
(2010). * Prahallad, A. et al. _Nature_ 483, 100–103 (2012). Article ADS CAS Google Scholar * Poulikakos, P. I., Zhang, C., Bollag, G., Shokat, K. M. & Rosen, N. _Nature_ 464,
427–430 (2010). Article ADS CAS Google Scholar * Nazarian, R. et al. _Nature_ 468, 973–977 (2010). Article ADS CAS Google Scholar * Poulikakos, P. I. et al. _Nature_ 480, 387–390
(2011). Article ADS CAS Google Scholar * Corcoran, R. B. et al. _Cancer Discov._ http://dx.doi.org/10.1158/2159-8290.CD-11-0341 (2012). * Di Nicolantonio, F. et al. _J. Clin. Oncol._ 26,
5705–5712 (2008). Article CAS Google Scholar * Joseph, E. W. et al. _Proc. Natl Acad. Sci. USA_ 107, 14903–14908 (2010). Article ADS CAS Google Scholar * Oberholzer, P. A. et al. _J.
Clin. Oncol._ 30, 316–321 (2012). Article CAS Google Scholar * Su, F. et al. _N. Engl. J. Med._ 366, 207–215 (2012). Article CAS Google Scholar * Infante, J. R. et al. _J. Clin.
Oncol._ 29 (ASCO Meet. Abstr. Pt 1), abstr. CRA8503 (2011). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * David B. Solit is in the Department of Medicine and the Human
Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA., David B. Solit * Pasi A. Jänne is at the Lowe Center for Thoracic Oncology, Dana
Farber Cancer Institute, Boston, Massachusetts 02215, USA., Pasi A. Jänne Authors * David B. Solit View author publications You can also search for this author inPubMed Google Scholar * Pasi
A. Jänne View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to David B. Solit or Pasi A. Jänne. RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Solit, D., Jänne, P. Primed for resistance. _Nature_ 483, 44–45 (2012). https://doi.org/10.1038/483044a Download citation *
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