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Access through your institution Buy or subscribe A robotic system that can carry out and analyse 1,536 chemical reactions in less than a day could help to accelerate drug discovery. Tim
Cernak and Spencer Dreher at pharmaceutical company Merck in Massachusetts and New Jersey and their colleagues used the system to couple a model substrate with 16 other molecules, in
combination with 16 different palladium catalysts and 6 basic reagents. Each of these unique mixtures was dissolved in 1 microlitre of solvent, automatically dispensed into a separate
chamber on a 1,536-well plate, and its products were analysed to determine optimum reaction conditions. This is a preview of subscription content, access via your institution ACCESS OPTIONS
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institutional subscriptions * Read our FAQs * Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rapid synthesis a thousand times.
_Nature_ 515, 468 (2014). https://doi.org/10.1038/515468d Download citation * Published: 26 November 2014 * Issue Date: 27 November 2014 * DOI: https://doi.org/10.1038/515468d SHARE THIS
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