ABSTRACT CD14, a pattern recognition receptor on monocyte and macrophage, plays a central role in innate immunity through recognition of bacterial lipopolysaccharide and initiation of

inflammatory response. Recently, CD14/−260C>T promoter gene polymorphism has been found to be related to a risk of inflammatory diseases. Our results showed that the C allele frequency

among Chinese in Taiwan was lower than those in Western countries. The membrane CD14 expression was significantly higher in TT as compared with CT and CC genotypes (_P_=0.034, 0.044,

respectively). There was a higher level of soluble CD14 in TT and CT genotypes than in CC genotypes. In addition, TNFα production in whole blood was significantly higher in TT genotype than

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WITH _CHLAMYDIA TRACHOMATIS_ INFECTION AND IN SILICO PREDICTION OF POTENTIALLY-RELATED PEPTIDES Article Open access 18 June 2021 FUNCTIONAL IMPACT OF ALLELIC VARIATIONS/HAPLOTYPES OF TNF-Α

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1435–1440. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We express our thanks to Ms Yuan-Jen Huang and Ms Chin-Fang Tsai for their technical assistance. This study was

supported by grants NSC89-2314B-182A-056 from the National Science Council, CMRPG8055 from Chang Gung University and Memorial Hospital, and MOE program for Promoting Academic Excellent of

University under the Grant Number 91-B-FA09-2-4 from Ministry of Education, Taiwan, Republic of China. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology, Chang Gung

University and Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China H L Eng * Department of Medical Technology, College of Medicine, National Cheng Kung

University, Tainan, Taiwan, Republic of China C H Wang, C T Cheng & T M Lin * Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of

China C H Chen * Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China M H Chou Authors * H L Eng View author

publications You can also search for this author inPubMed Google Scholar * C H Wang View author publications You can also search for this author inPubMed Google Scholar * C H Chen View

author publications You can also search for this author inPubMed Google Scholar * M H Chou View author publications You can also search for this author inPubMed Google Scholar * C T Cheng

View author publications You can also search for this author inPubMed Google Scholar * T M Lin View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to T M Lin. ADDITIONAL INFORMATION This study was presented in part as a poster (P036) at the 22nd World Congress of Pathology and Laboratory Medicine,

August 2003, Busan, Korea. Informed consent was obtained from participants, and the study was approved by the National Cheng Kung University Hospital Research Ethics Committee. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Eng, H., Wang, C., Chen, C. _et al._ A CD14 promoter polymorphism is associated with CD14 expression and

Chlamydia-stimulated TNFα production. _Genes Immun_ 5, 426–430 (2004). https://doi.org/10.1038/sj.gene.6364100 Download citation * Received: 26 January 2004 * Revised: 24 March 2004 *

Accepted: 30 March 2004 * Published: 27 May 2004 * Issue Date: 01 July 2004 * DOI: https://doi.org/10.1038/sj.gene.6364100 SHARE THIS ARTICLE Anyone you share the following link with will be

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initiative KEYWORDS * CD14 polymorphism * TNFα * _Chlamydia_ * LPS