ABSTRACT Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic liver disease most commonly encountered in postmenopausal women; it is characterized by high-titer serum

autoantibodies to mitochondrial antigens, elevated serum IgM, progressive destruction of intrahepatic bile ducts, and ultimately liver cirrhosis and failure. The cytopathic mechanisms

leading to the selective destruction of intrahepatic cholangiocytes are still largely unknown. The current theory on the pathogenesis of PBC indicated that environmental factors might

trigger autoimmunity in genetically susceptible individuals. In fact, genetic predisposition is critical to disease onset and progression, yet peculiar among autoimmune diseases, as

regarding the genetic factors associated with PBC susceptibility and progression, as well as the available evidence regarding the immunomediated pathogenesis of PBC, will be critically

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AUTOIMMUNE DISEASES BASED ON MENDELIAN RANDOMIZATION Article Open access 21 May 2024 RISK OF HEPATOCELLULAR CARCINOMA AND CIRRHOSIS DECOMPENSATION IN A LARGE RETROSPECTIVE COHORT OF

CIRRHOTIC PATIENTS WITH AUTOIMMUNE HEPATITIS Article Open access 16 April 2025 _MARC1_ P.A165T VARIANT IS ASSOCIATED WITH DECREASED MARKERS OF LIVER INJURY AND ENHANCED ANTIOXIDANT CAPACITY

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Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Internal Medicine, San Paolo School of Medicine, University of Milan, Milan, Italy C Selmi, P

Invernizzi, M Zuin & M Podda * Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, 95616, CA, USA C Selmi, M F Seldin & M E Gershwin

* Biochemistry and Rowe Program in Human Genetics, University of California at Davis, School of Medicine, Davis, CA, USA M F Seldin Authors * C Selmi View author publications You can also

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Correspondence to M E Gershwin. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Selmi, C., Invernizzi, P., Zuin, M. _et al._ Genes and (auto)immunity in

primary biliary cirrhosis. _Genes Immun_ 6, 543–556 (2005). https://doi.org/10.1038/sj.gene.6364248 Download citation * Received: 17 June 2005 * Accepted: 17 June 2005 * Published: 21 July

2005 * Issue Date: 01 October 2005 * DOI: https://doi.org/10.1038/sj.gene.6364248 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

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cholangitis * complex disease * association study * environmental factors * pathogenesis