ABSTRACT Oncoprotein 18/stathmin (Op18) is a conserved cytosolic phosphoprotein that regulates microtubule dynamics. The microtubule destabilizing activity is regulated by phosphorylation,

mediated by both growth factor stimulated- and cell-cycle regulating kinases. The protein is highly expressed in a variety of human malignancies. In human breast carcinoma, Op18 has

previously been shown to be up-regulated in a subset of the tumours, however, no correlation with clinicopathologic characteristics has been reported so far. In the present study we have

examined Op18 protein expression by quantitative Western blot analysis in a panel of 151 semi-consecutive breast carcinoma samples. Op18 levels were negatively correlated with oestrogen

is not restricted to a specific sub-group of breast carcinoma. © 2000 Cancer Research Campaign SIMILAR CONTENT BEING VIEWED BY OTHERS HIGH FORMIN BINDING PROTEIN 17 (FBP17) EXPRESSION

INDICATES POOR DIFFERENTIATION AND INVASIVENESS OF DUCTAL CARCINOMAS Article Open access 14 July 2020 SURVIVAL ANALYSIS IN BREAST CANCER USING PROTEOMIC DATA FROM FOUR INDEPENDENT DATASETS

Article Open access 18 August 2021 HISTOLOGIC AND GENOMIC FEATURES OF BREAST CANCERS WITH ALTERATIONS AFFECTING THE SWI/SNF (SMARC) GENES Article 02 June 2021 ARTICLE PDF CHANGE HISTORY * _

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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Chemistry, Umeå University Hospital, Umeå, S-901 85, Sweden G Brattsand Authors * G Brattsand View

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ABOUT THIS ARTICLE CITE THIS ARTICLE Brattsand, G. Correlation of oncoprotein 18/stathmin expression in human breast cancer with established prognostic factors. _Br J Cancer_ 83, 311–318

(2000). https://doi.org/10.1054/bjoc.2000.1264 Download citation * Received: 16 December 1999 * Revised: 30 March 2000 * Accepted: 10 April 2000 * Published: 04 July 2000 * Issue Date: 01

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link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * oncoprotein 18 * stathmin * breast cancer

* oestrogen receptor * Western blot