ABSTRACT Loss of heterozygosity (LOH) is frequent at the chromosomal region 11q22–q23 in several types of tumours of diverse cell origin. Previous investigations of LOH at this chromosomal

region in colorectal carcinoma have been contradictory in their findings, and have only included between 1–4 loci. In order to define any regions of LOH on 11q23, we investigated 16 loci

between D11S940 and D11S934 on the long arm of chromosome 11 using microsatellite analysis. Of 57 colorectal carcinomas specimens, 36 (63.2%) demonstrated LOH at one or more marker, with the

highest frequencies of LOH at D11S1340 (41.0%), located between 105.13–111.97 Mb from the centromere, and D11S924 (37.1%) and D11S4107 (40.5%), both located approximately 113 Mb from the

putative tumour suppressor gene(s) at chromosome 11q23, involved in the carcinogenesis of colorectal carcinoma, and will facilitate future identification of candidate genes. © 2000 Cancer

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mortality, 1973–1995. _Cancer_ 82: 1197–1207 Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Research, Outram

Road, 169608, Republic of Singapore A S-G Lee, Y-C Seo, A Chang & S Tohari * Department of Colorectal Surgery, Singapore General Hospital, Outram Road, 169608, Republic of Singapore K-W

Eu & F Seow-Choen * Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK J O'D McGee * Division of Medical Sciences, National Cancer Centre, 169610,

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http://creativecommons.org/licenses/by-nc-sa/3.0/ Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lee, AG., Seo, YC., Chang, A. _et al._ Detailed deletion mapping at chromosome

11q23 in colorectal carcinoma. _Br J Cancer_ 83, 750–755 (2000). https://doi.org/10.1054/bjoc.2000.1366 Download citation * Received: 06 December 1999 * Revised: 11 May 2000 * Accepted: 08

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initiative KEYWORDS * loss of heterozygosity (LOH) * chromosome 11q * tumour suppressor genes * colorectal carcinoma