ABSTRACT _Purpose_ (1) To see the effectiveness of applying the criteria laid down by the American college of Rheumatology in the diagnosis of giant cell arteritis (GCA). (2) To quantify the

role of temporal artery biopsy (TAB) in diagnosing GCA using the Greenwich grading system. _Methods_ A retrospective case notes review of consecutive patients undergoing TAB over 6 years,

from 1995 to 2000, in a UK hospital eye unit was done. The American college of Rheumatology 1990 criteria for diagnosis of GCA were applied. A detailed analysis of age of onset, mode of

presentation, laboratory findings and histology was done for all the patients. In an attempt to quantify the clinical value of TAB in patients with clinically suspected GCA, the Greenwich

Temporal headache, ESR>50 mm/h and temporal artery tenderness were found to occur more often in patients with positive biopsy. _Conclusion_ (1) The American College of Rheumatology

criteria provide a framework in which the clinician can continually assess the need for TAB. (2) The Greenwich grading system, as applied in evaluating the role of TAB in the management of

GCA, demonstrated the clinical usefulness of this invasive procedure in the majority of cases. It identified the patient groups that benefit the most from a TAB. SIMILAR CONTENT BEING VIEWED

BY OTHERS ROLE OF TEMPORAL ARTERY BIOPSY IN A SEQUENTIAL GIANT CELL ARTERITIS FAST-TRACK PATHWAY: A 5-YEAR PROSPECTIVE STUDY Article 10 August 2022 COMPARISON OF TEMPORAL ARTERY ULTRASOUND

VERSUS BIOPSY IN THE DIAGNOSIS OF GIANT CELL ARTERITIS Article 29 January 2022 GIANT CELL ARTERITIS: REVIEWING THE ADVANCING DIAGNOSTICS AND MANAGEMENT Article Open access 14 February 2023

INTRODUCTION Giant Cell Arteritis (GCA) is a polysymptomatic disease affecting the elderly, with a wide variety of local and systemic clinical manifestations. Onset of symptoms may either be

abrupt or gradually progressive, depending on the artery involved. Systemic features include headache, scalp (temporal) tenderness, jaw claudication, malaise, anorexia, weight loss, fever,

and arthralgia. These usually precede ophthalmological symptoms. The incidence of ocular involvement in GCA ranges between 14% and 70% in different series.1,2,3 A silent or occult

presentation has been reported in up to 38% of the cases.1 The most common ophthalmic manifestation of GCA is anterior ischaemic optic neuropathy. Other ophthalmic presenting features

include amaurosis fugax and diplopia. Histology of GCA consists of granulomatous inflammation, disruption of the internal elastic lamina, proliferation of the intima, and complete stenosis

of the lumen. Diagnosis of GCA requires the association of multiple factors, but TAB finally establishes the diagnosis. When classic symptoms are present, diagnosis is easily addressed.

However, classic symptoms are not always present, and vague symptoms may sometimes be unrecognised by the patient. The clinician should have a high index of suspicion in order to diagnose

GCA in the absence of the typical presentation. According to the American College of Rheumatology 1990 criteria,4 diagnosis of GCA is made when at least three of the following five criteria

are met: * 1 age at onset of 50 years or older, * 2 new onset of localised headache, * 3 temporal artery tenderness or decreased pulse, * 4 elevated erythrocyte sedimentation rate (>50 

mm/h) by the Westergren method, and * 5 Positive histology findings. In our study, the effectiveness of the American College of Rheumatology criteria in diagnosing GCA was evaluated and an

attempt was made to quantify the role of TAB in the management of GCA using a grading system known as the ‘Greenwich grading system’. GREENWICH GRADING SYSTEM This is a simple method

developed by Corbett _et al_5 for assessing the value of a clinical investigation. It is designed such that it is easy to use in any clinical situation and applicable to any investigation.

The role of the investigation in the management of a given patient is expressed by a single grade: essential (3), important (2), helpful (1), unnecessary (0) or adverse (−1) (Tables 1 and

2). The degree to which an investigation can influence the diagnosis is dependent upon the certainty of the clinician's diagnosis and the certainty with which the investigation can

change, make, confirm, or exclude a diagnosis. It is of particular value when it is the only test, which can give the required answer. A test can potentially adversely affect the overall

outcome if undertaking it delays a more valuable investigation. METHODS A retrospective case notes review of consecutive patients undergoing TAB over 6 years, from 1995 to 2000, in a UK

hospital eye unit was conducted. Of the 61 patients who underwent TAB during this period, only 53 case notes could be retrieved. Based on the American college of Rheumatology 1990 criteria4

for diagnosis of GCA, a scoring system was adopted. Each patient was given a scoring of 1 point for each criterion that they met. A diagnosis of GCA was made when they scored a total of at

least 3 points. A detailed analysis of age of onset, mode of presentation, laboratory findings, and histology was carried out for all the patients. In an attempt to quantify the clinical

value of TAB in patients with clinically suspected GCA, the Greenwich grading system was used. The impact of a TAB on the management of these patients was assessed in the context of

available alternatives. The overall value of TAB in the management of GCA was graded as essential, important, helpful, unnecessary, and adverse effect. RESULTS Case notes of 53 patients who

underwent TAB over a period of 6 years from January 1995 to December 2000 were reviewed. Out of these, 13 patients were found to have positive TAB, while 40 patients had negative biopsies.

On application of the American College of Rheumatology criteria for the diagnosis of GCA, 36 patients fulfilled the criteria required to make a diagnosis of GCA. In our study, each of the

American College of Rheumatology criteria was applied in order to evaluate its validity and its relation to biopsy findings. 1. AGE AT ONSET The age distribution of the patients in relation

to biopsy findings in this study were as follows: A (Table 3) total of 53 patients were entered in this study. The mean age at presentation in patients undergoing TAB was 69 years and the

mean age of patients with positive biopsy was 74 years. None of our patients were of Asian or Black ethnic origin. Applying the American College of Rheumatology criteria, only two out of 53

patients with clinically suspected GCA were less than 50 years of age. In both these patients, the TAB was negative and they did not fulfil the criteria for the diagnosis of GCA. Of the 13

patients with positive biopsy, the age of onset was more than 70 years in the majority of patients. This implies that the more advanced the age the higher the likelihood of GCA. 2. NEW ONSET

OF LOCALISED HEADACHE Out (Table 4) of 53 patients in the entire cohort, 13 patients had a positive biopsy. The American College of Rheumatology criteria were applied. New onset headache

was the presenting symptom in 36 patients. In the remaining patients, presenting symptoms included tender temples, visual disturbances such as amaurosis fugax and visual loss secondary to

anterior ischaemic optic neuropathy, and central retinal artery occlusion. In all, 10 out of 13 patients with positive biopsy complained of a new onset headache, while the remaining three

presented with visual loss. This implies that absence of headache does not rule out GCA as a possible diagnosis. 3. TEMPORAL ARTERY TENDERNESS Of (Table 5) the 53 patients who were included

in this study, 29 complained of tenderness over the temporal artery. Out of these, 19 patients had a negative biopsy and 10 patients had a positive biopsy. Three out of 13 patients with

positive TAB in the study had a nontender temple with good temporal artery pulsations, suggesting that lack of temple tenderness does not exclude GCA. The majority of patients with positive

biopsy had temporal tenderness, implying that tenderness over the temporal artery is a reliable sign of GCA occurrence. 4. INCREASED ESR In (Table 6) total, 35 of the 53 patients, had

elevated ESR. Out of these, 24 patients had a negative TAB and 11 patients had a positive biopsy. Of the 13 patients with positive TAB in the entire study, a majority (11/13) of the patients

had elevated ESR, although two patients had a normal ESR. 5. POSITIVE HISTOLOGY Of the 53 patients with clinically suspected GCA, positive biopsy was present in 13 patients. Biopsies were

considered positive on the basis of the final report issued by the pathologist. Most of the biopsies considered positive had classical histological features of GCA consisting of

granulomatous vasculitis with a predominance of mononuclear cell inflammation, usually with multinucleated giant cells. Applying the American College of Rheumatology criteria to the data

from this study, it was noted that out of the 53 patients who underwent a TAB for clinically suspected GCA, positive biopsy was present in 13 patients and hence the diagnosis was confirmed

in these patients. GCA was excluded in 15 patients who did not fulfil the American College of Rheumatology criteria for diagnosing GCA and had a negative biopsy. Treatment was altered, that

is, steroids stopped following the TAB result in eight patients. All patients with positive biopsy fulfilled the American College of Rheumatology criteria for diagnosing GCA implying that

the American College of Rheumatology criteria are of clinical importance in diagnosing GCA. APPLICATION OF THE GREENWICH GRADING SYSTEM The Greenwich grading system was easy to apply

retrospectively in all the patients. The overall value of TAB in the management of GCA was graded as essential, important, helpful, unnecessary, and adverse effect. Out of the 53 patients

reviewed in this study, TAB was noted to be of value in 32 (61%) patients. This figure was obtained by addition of patients in the subgroups ‘essential’, ‘important’, and ‘helpful’ (Table

2). In 21 (39%) patients (‘unnecessary’ subgroup) with clinically suspected GCA, TAB was thought to be of no additional value. Either these patients had more than three criteria for the

diagnosis of GCA and were treated with steroids regardless of the biopsy findings or there was one or less criterion which therefore made diagnosis of GCA unlikely. In no patient did this

investigation adversely affect the clinical outcome. DISCUSSION GCA usually occurs in people older than 60 years with a mean age at presentation of 71 years. Salvarani and co-workers noted

that the incidence of GCA increased by 2.6% every 5 years.14 Comparable results were obtained in our study with mean age of patients at presentation being 69 years and in those with positive

biopsy the mean age was 74 years. The incidence of GCA was noted to be higher among patients greater than 70 years of age. GCA rarely occurs in Asian and black populations. None of our

patients were of Asian or Black ethnic origin. A normal erythrocyte sedimentation rate in patients with biopsy-proven GCA was reported in 8% of patients by Hayreh _et al_7 and 15% by von

Blotzein and Borruat.8 In our study, normal ESR was noted in 15% of biopsy-proven GCA. In agreement with findings in other studies, temporal headache, ESR >50 mm/h, and tenderness over

the temporal artery were found to occur more often in patients with positive biopsy. There are few data to guide clinicians in making decisions about treatment when the clinical evidence for

GCA is insufficient. Hunder _et al_4 developed the American College of Rheumatology criteria 1990 for diagnosing GCA. They compared 214 patients who had this disease with 593 patients with

other forms of vasculitis (controls). They concluded that the presence of three or more of these five criteria for diagnosing GCA was associated with a sensitivity of 93.5% and specificity

of 91.2%. In our study using the American College of Rheumatology 1990 criteria, TAB was seen to be of limited value in altering the course of management when the diagnosis was certain (ie

patients with presence of four criteria) and steroids were commenced irrespective of the biopsy findings. In patients where the diagnosis of GCA was probable or possible (ie with presence of

two criteria or with atypical presentation), TAB was found to be of increasing benefit. Patients included in the former category belonged to the ‘unnecessary’ subgroup, and to the essential

and important subgroup in the latter (Table 2). GCA is a systemic disease that can have devastating ophthalmic consequences. Increasing awareness of this disease among clinicians often

causes early initiation of treatment with systemic steroids. However, GCA can be incorrectly diagnosed in elderly patients with high ESR and pain in the temporal area. Such an incorrect

diagnosis can subject the patient to needless biopsy and the serious side effects of therapy with large doses of systemic steroids. Although uncommon, complications related to TAB such as

postoperative haematoma, scalp necrosis, wound infection, damage to facial nerve, and drooping of eyebrow can occur. TAB as a diagnostic tool for GCA is not perfectly sensitive, with

reported rates of 70–90%.9 The diagnostic value of TAB has been questioned because of low sensitivity. On the other hand, many physicians have emphasised the high value of a positive biopsy

before commencing high doses of systemic steroids. TAB is a highly specific invasive investigation for GCA. Positive TAB confirms the diagnosis, but a negative biopsy does not exclude GCA.

This is due to the segmental nature of GCA. Areas of unaffected tissue (skip lesions) are reported in 21–28% of cases,10 leading to a 5–61% incidence of false-negative biopsies.10,11 Several

methods have been proposed to increase the diagnostic accuracy of TAB such as removing a longer segment of artery or taking a contralateral biopsy specimen. Furthermore, the selection of

the biopsy site by palpation, angiography, or Doppler and multiple sectioning of the specimen have been proposed. Thus in many cases, the diagnosis has to be established upon certain

clinical features and laboratory findings, which help clinicians to differentiate GCA from other disorders. Some physicians feel that a high rate of false-negative biopsies diminishes the

value of the procedure and there remains some controversy about its therapeutic impact. In order to improve the efficiency of the service and decrease rates of inappropriate referral for any

investigation, it is important that only patients in whom real diagnostic uncertainty exists are referred. Various workers have studied the diagnostic value of TAB and its cost

effectiveness. There are different opinions about the usefulness of a TAB in patients with clinically suspected GCA. Vilaseca _et al_12 assessed the diagnostic usefulness of TAB in GCA. They

performed a retrospective study of the biopsy specimens and clinical features of 103 patients who had undergone TAB over 14 years. They concluded that using criteria proposed by Ellis and

Ralston, TAB reached a diagnostic sensitivity of 81.8%, with a positive predictive value of 90.2%. Skaug _et al_13 also studied the clinical usefulness of a TAB in diagnosing GCA. They

concluded that the high frequency of negative results of TAB performed as a routine procedure in patients suspected of GCA justifies further research regarding an improvement of the

sensitivity of this test or the development of other tests with better predictive values. Using the American College of Rheumatology criteria 1990 for diagnosis of GCA in our study, TAB was

found to be 100% specific (ie those with a positive biopsy and also fulfilled the criteria required for GCA diagnosis) and reached a positive predictive value of 100%. SIGNIFICANCE OF THE

GREENWICH GRADING SYSTEM IN OUR STUDY In our study, using the Greenwich grading system, a comparison of the value of TAB in different groups of patients was carried out to determine those in

whom referral for biopsy was the most or least appropriate. The Greenwich grading system helped in identifying the patients with clinically suspected GCA who benefit most from a TAB. This

included patients in the ‘essential’ and ‘important’ subgroup (Table 2). We feel this will reduce inappropriate TAB referrals and provide assistance to clinicians in deciding the need for a

TAB. To the best of our knowledge, the quantification of the role of TAB in the management of GCA using the Greenwich grading system has not been done before. CONCLUSIONS * 1 The American

College of Rheumatology criteria provide a framework in which the clinician can continually assess the need for TAB. This would promote good practice and ease the clinical dilemma for

diagnosis of GCA. * 2 The Greenwich grading system, as applied in evaluating the role of TAB in the management of GCA, demonstrated the clinical usefulness of this invasive procedure in

majority of the cases. * 3 The Greenwich grading system identified the patient groups, which benefit most from a temporal artery biopsy. REFERENCES * Hayreh SS, Podhajsky PA, Zimmerman B .

Ocular manifestations of giant cell arteritis. _Am J Ophthalmol_ 1998; 125: 509–520. Article  CAS  Google Scholar  * Ghanchi FD, Dutton GN . Current concepts in giant cell (temporal)

arteritis. _Surv Ophthalmol_ 1997; 42: 99–122. Article  CAS  Google Scholar  * Gur H, Rapman E, Ehrenfeld M, Sidi Y . Clinical manifestations of temporal arteritis: a report from Israel. _J

Rheumatol_ 1996; 23: 1927–1931. CAS  PubMed  Google Scholar  * Hunder GG, Bloch DA, Michel BA, Stevens MB, Avend WP, Catabrese LH _et al_. The American College of Rheumatology 1990 criteria

for the classification of Giant cell arteritis. _Arthritis a Rheum_. 1990; 33(8) 1122–1128. Article  CAS  Google Scholar  * Corbett MC, Shilling JS, Holder GE . The assessment of clinical

investigations: The Greenwich grading system and its application to electro diagnostic testing in ophthalmology. _Eye_ 1995; 9: 59–64. PubMed  Google Scholar  * Jose L . Tovilla-Canales.

Ocular manifestations of giant cell arteritis. _Curr Opin Ophthalmol_ 1998; 9: 73–79. Article  Google Scholar  * Hayreh SS, Podhajsky PA, Raman R, Zimmerman B . Giant cell arteritis:

validity and reliability of various diagnostic criteria. _Am J Ophthalmol_ 1997; 123: 285–296. Article  CAS  Google Scholar  * Von Blotzein SG, Borruat FX . Arterite a cellules geantes et

vitesse de sedimentation normale: plus que’une exception. _Klin Monatsbl Augenheilkd_ 1996; 208: 397–399. Article  Google Scholar  * Mizen TR . Giant cell arteritis: diagnostic and

therapeutic considerations. _Ophthalmol Clin North Am_ 1991; 4: 547–556. Google Scholar  * Wells KK, Folberg R, Goeken JA, Kemp JD . Temporal artery biopsies: cor-relation of light

microscopy and immunofluorescence microscopy. _Ophthalmology_ 1989; 96: 1058–1064. Article  CAS  Google Scholar  * Weyand CM, Bartley GB . Giant cell arteritis: new concepts in pathogenesis

and implications for management. _Am J Ophthalmol_ 1997; 123: 392–395. Article  CAS  Google Scholar  * Vilaseca J, Gonzalez A, Cid MC, Lopez-Vivancos J, Ortega A . Clinical usefulness of

temporal artery biopsy. _Ann Rheum Dis._ 1987; 46(4) 282–285. Article  CAS  Google Scholar  * Skaug TR, Midelfart A, Jacobsen G . Clinical usefulness of biopsy in giant cell arteritis. _Acta

Ophthalmol Scand_. 1995; 73: 567–570. Article  CAS  Google Scholar  * Salvarani C, Gabriel SE, O'Fallon M, Hunder GC . The incidence of giant cell arteritis in Olmsted county,

Minnesota: apparent fluctuations in a cyclic pattern. _Ann Intern Med_ 1995, 123: 192–194. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Department of Ophthalmology, SPR Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, UK D Varma & D O'Neill Authors * D Varma View author publications You can also search

for this author inPubMed Google Scholar * D O'Neill View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to D Varma.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Varma, D., O'Neill, D. Quantification of the role of temporal artery biopsy in diagnosing clinically

suspected giant cell arteritis. _Eye_ 18, 384–388 (2004). https://doi.org/10.1038/sj.eye.6700677 Download citation * Received: 12 December 2002 * Accepted: 10 June 2003 * Published: 07

April 2004 * Issue Date: 01 April 2004 * DOI: https://doi.org/10.1038/sj.eye.6700677 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * temporal

artery biopsy * greenwich grading system * American College of Rheumatology