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ABSTRACT Measurement error in exposure assessment is unavoidable. Statistical methods to correct for such errors rely upon a valid error model, particularly regarding the classification of
classical and Berkson error, the structure and the size of the error. We provide a detailed list of sources of error in residential radon exposure assessment, stressing the importance of (a)
the differentiation between classical and Berkson error and (b) the clear definitions of predictors and operationally defined predictors using the example of two German case–control studies
on lung cancer and residential radon exposure. We give intuitive measures of error size and present evidence on both the error size and the multiplicative structure of the error from three
data sets with repeated measurements of radon concentration. We conclude that modern exposure assessment should not only aim to be as accurate and precise as possible, but should also
provide a model of the remaining measurement errors with clear differentiation of classical and Berkson components. Access through your institution Buy or subscribe This is a preview of
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FOR ENVIRONMENTAL EXPOSURE AND BIOMONITORING DATA WITH REPEATED MEASUREMENTS AND VALUES BELOW THE LIMIT OF DETECTION Article 22 January 2024 USING LOW-COST SENSOR TECHNOLOGIES AND ADVANCED
COMPUTATIONAL METHODS TO IMPROVE DOSE ESTIMATIONS IN HEALTH PANEL STUDIES: RESULTS OF THE AIRLESS PROJECT Article 12 August 2020 LUNG CANCER MORTALITY ATTRIBUTABLE TO RESIDENTIAL RADON: A
SYSTEMATIC SCOPING REVIEW Article 28 December 2022 REFERENCES * Armstrong B.G. The effects of measurement errors on relative risk regression. _Am J Epi_ 1990: 132(6): 1176–1184. Article CAS
Google Scholar * Bäverstam U., and Swedjemark G.A. Where are the errors when we estimate radon exposure in retrospect? _Radiat Prot Dosim_ 1991: 36(2/4): 107–112. Article Google Scholar
* Carroll R.J., Ruppert D., and Stefanski L.A. _Measurement Error in Nonlinear Models_. Chapman & Hall, London, 1995. Book Google Scholar * Carroll R.J., Spiegelmann C., Lan K.K.,
Bailey K.T., and Abbott R.D. On errors-in-variables for binary regression models. _Biometrika_ 1984: 74: 19–26. Article Google Scholar * Darby S., Whitley E., Silcocks P., Thakrar B.,
Green M., Lomas P., Miles J., Reeves G., Fearn T., and Doll R. Risk of lung cancer associated with residential radon exposure in south-west England: a case–control study. _Br J Cancer_ 1998:
78(3): 394–408. Article CAS Google Scholar * Gerken M., Kreienbrock L., Wellmann J., Kreuzer M., and Wichmann H.E. Models for retrospective quantification of indoor radon exposure in
case-control studies. _Health Phys_ 2000: 78(3): 268–278. Article CAS Google Scholar * Gunby J.A., Darby S.C., Miles J.C.H., Green B.M.R., and Cox D.R. Factors affecting indoor radon
concentration in the United Kingdom. _Health Phys_ 1993: 64: 2–12. Article CAS Google Scholar * Hardcastle G.D., and Miles J.C.H. Ageing and fading of alpha particle tracks in CR-39
exposed to air. _Radiat Prot Dosim_ 1996: 67: 295–298. Article CAS Google Scholar * Heid I.M. Measurement error in exposure assessment: an error model and its impact on studies of lung
cancer and residential radon exposure in Germany. PhD Thesis, 2002. http://edoc.ub.uni-muenchen.de/archive/00000522/. * Heid I.M., Küchenhoff H., Wellmann J., Gerken M., Kreienbrock L., and
Wichmann H.E. On the potential of measurement error to induce differential bias on risk estimates: an example from radon epidemiology. _Stat Med_ 2002: 21: 3261–3278. Article CAS Google
Scholar * International Commission on Radiological Protection (ICRP). _Lung cancer risk from indoor exposures to radon daughters_. ICRP Publ Nr. 50. Pergamon Press, New York, 1994. * Jacobi
W. The dose to the human respiratory tract by inhalation of short-lived 222Rn-and 220 Rn-decay products. _Health Phys_ 1964: 10: 1163–1174. Article CAS Google Scholar * Jacobi W. Dose to
tissue and effective dose equivalent by inhalation of radon-222, radon-220 and their short-lived daughters. GSF-report S-626, Neuherberg,, 1989. * Kreienbrock L., Kreuzer M., Gerken M.,
Dingerkus G., Wellmann J., Keller G., and Wichmann H.E. Case-control study on lung cancer and residential radon in West Germany. _Am J Epidemiol_ 2001: 153(1): 42–52. Article CAS Google
Scholar * Kreienbrock L., Poffijn A., Tirmarche M., Feider M., Kies A., and Darby S.C. Intercomparison of passive radon-detectors under field conditions in epidemiological studies. _Health
Phys_ 1999: 76(5): 558–563. Article CAS Google Scholar * Kreuzer M., Heinrich J., Wölke G., Schaffrath Rosario A., Gerken M., Wellmann J., Keller G., Kreienbrock L., and Wichmann H.E.
Residential radon and risk of lung cancer in Eastern Germany. _Epidemiology_ 2003: 14: 559–568. Article Google Scholar * Lagarde F., Falk R., Almren K., Nyberg F., Svensson H., and
Pershagen G. Glass-based radon-exposure assessment and lung cancer risk. _J Expo Anal Environ Epidemiol_ 2002: 12: 344–354. Article CAS Google Scholar * Lagarde F., Pershagen G., Akerblom
G., Axelson O., Bäverstam U., Damber L., Enflo A., Svartengren M., and Swedjemark G.A. Residential radon and lung cancer in Sweden: risk analysis accounting for random error in the exposure
assessment. _Health Phys_ 1997: 72: 269–276. Article CAS Google Scholar * Lubin J.H., Boice J.D., Edling C.H., Hornung R., Howe G., Kunz E., Kusiak A., Morrison H.I., Radford E.P., Samet
J.M., Tirmarche M., Woodward A., Xiang Y.S., and Pierce D.A. Radon and lung cancer risk: a joint analysis of 11 underground miner studies. NIH publication no. 94-3644, Rockville, MD, 1994.
* Lubin J.H., Boice Jr J.D., and Samet J.M. Errors in exposure assessment, statistical power and the interpretation of residential radon studies. _Radiat Res_ 1995: 144: 329–341. Article
CAS Google Scholar * Mallick B., Hoffmann F.O., and Carroll R.J. Semiparametric regression modeling with mixtures of Berkson and classical error, with application to fallout from the
Nevada test stite. _Biometrics_ 2002: 58: 13–20. Article Google Scholar * Michels K.B. A renaissance for measurement error. _Int J Epidemiol_ 2001: 30: 421–422. Article CAS Google
Scholar * National Academy of Sciences (NAS) National Research Council. Health effects of exposure to radon: time for reassessment? BEIR VI Report of the Committee on the Biological Effects
of Ionizing Radiation, National Academy Press, Washington, DC, 1994. * Pershagen G., Axelson O., Clavensjö B., Damber L., Desai G., Enflo A., Lagarde F., Mellander H., Svartengren M.,
Swedjemark G.A., and Akerblom G. Residential radon exposure and lung cancer in Sweden. _N Engl J Med_ 1994: 330: 159–164. Article CAS Google Scholar * Poffijn A., Tirmarche M.,
Kreienbrock L., Kayser B., and Darby S.C. Radon and lung cancer: protocol and procedures of the multi-centre studies in the Ardennes-Eifel region, Brittany, and the Massiv Central. _Radiat
Prot Dosim_ 1992: 45(Suppl 1/4): 651–656. Article Google Scholar * Reeves G.K., Cox D.R., Darby S.C., and Whitley E. Some aspects of measurement error in explanatory variables for
continuous and binary regression models. _Stat Med_ 1998: 17: 2157–2177. Article CAS Google Scholar * Rosner B., Willett W.C., and Spiegelman D. Correction of logistic regression relative
risk estimates and confidence intervals for systematic within-person measurement error. _Stat Med_ 1989: 8: 1051–1069. Article CAS Google Scholar * Schafer D.W., Lubin J.H., Ron E.,
Stovall M., and Carroll R.J. Thyroid cancer following scalp irradiation: a reanalysis accounting for uncertainty in dosimetry. _Biometrics_ 2001: 57: 689–697. Article CAS Google Scholar *
Tosteson T.D., Stefanski L.A., and Schafer D.W. A measurement-error model for binary and ordinal regression. _Stat Med_ 1989: 8: 1139–1147. Article CAS Google Scholar * Wichmann H.E.,
Gerken M., Wellmann J., Kreuzer M., Kreienbrock L., Keller G., Wölke G., and Heinrich J. Lungenkrebsrisiko durch Radon in der Bundesrepublik Deutschland (Ost) - Thüringen und Sachsen (in
German). _Fortschritte in der Umweltmedizin._ ecomed verlagsgesellschaft, 1999. * Wichmann H.E., Kreienbrock L., Kreuzer M., Gerken M., Dingerkus G., Wellmann J., and Keller G.
Lungenkrebsrisiko durch Radon in der Bundesrepublik Deutschland (West) (in German). _Fortschritte in der Umweltmedizin_. ecomed verlagsgesellschaft, 1998. * Wrixon A.D., Green B.M.R., Lomas
P.R.M., Miles J.C.H., Cliff K.D., Francis E.A., Driscoll C.M.H., James A.C., and O’Riordan M.X. Natural radiation exposure in UK dwellings. NRPB R-190, 1988. * Zeger S.L., Thomas D.,
Dominici F., Samet J.M., Schwartz J., Dockery D., and Cohen A. Exposure measurement error in time-series studies of air pollution: Concepts and consequences. _Environ Health Perspect_ 2000:
108(5): 419–426. Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * GSF-National Research Center for Environment and Health, Insitute of
Epidemiology, Neuherberg, Germany I M Heid & H E Wichmann * Department of Statistics, Ludwig-Maximilians-Universtität München, Munich, Germany H Küchenhoff * National Radiation
Protection Board, Oxford, UK J Miles * Institute for Biometry, Epidemiology and Information Processing, Hanover School of Veterinary Medicine, Hanover, Germany L Kreienbrock Authors * I M
Heid View author publications You can also search for this author inPubMed Google Scholar * H Küchenhoff View author publications You can also search for this author inPubMed Google Scholar
* J Miles View author publications You can also search for this author inPubMed Google Scholar * L Kreienbrock View author publications You can also search for this author inPubMed Google
Scholar * H E Wichmann View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to I M Heid. RIGHTS AND PERMISSIONS Reprints
and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Heid, I., Küchenhoff, H., Miles, J. _et al._ Two dimensions of measurement error: Classical and Berkson error in residential radon
exposure assessment. _J Expo Sci Environ Epidemiol_ 14, 365–377 (2004). https://doi.org/10.1038/sj.jea.7500332 Download citation * Received: 27 February 2003 * Accepted: 28 October 2003 *
Published: 13 September 2004 * Issue Date: 01 September 2004 * DOI: https://doi.org/10.1038/sj.jea.7500332 SHARE THIS ARTICLE Anyone you share the following link with will be able to read
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KEYWORDS * measurement error * Berkson error * error models * error sources * radon * case–control studies.