ABSTRACT Cardiovascular disease is the most common cause of death in the diabetic population and is currently one of the leading causes of death in the United States and other industrialized

countries. The health care expenses associated with cardiovascular disease are staggering, reaching more than US$350 billion in 2003. The risk factors for cardiovascular disease include

high fat/cholesterol levels, alcoholism, smoking, genetics, environmental factors and hypertension, which are commonly used to gauge an individual's risk of cardiovascular disease and

to track their progress during therapy. Most recently, these factors have become important in the early prevention of cardiovascular diseases. Oxidative stress, the imbalance between

recent advances in oxidative stress theory and antioxidant therapy in diabetic cardiomyopathy, with an emphasis on the stress signaling pathways hypothesized to be involved. Many of these

stress signaling pathways lead to activation of reactive oxygen species, major players in the development and progression of diabetic cardiomyopathy. SIMILAR CONTENT BEING VIEWED BY OTHERS

THE INTEGRATED STRESS RESPONSE IN ISCHEMIC DISEASES Article 06 November 2021 REACTIVE OXYGEN SPECIES IN HYPERTENSION Article 24 July 2024 OXIDATIVE STRESS AND THE ROLE OF REDOX SIGNALLING IN

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, Grand Forks, 58203, ND, USA Loren E Wold & Jun Ren *

Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, 82071, WY, USA Asli F Ceylan-isik & Jun Ren Authors * Loren E Wold View author publications

You can also search for this author inPubMed Google Scholar * Asli F Ceylan-isik View author publications You can also search for this author inPubMed Google Scholar * Jun Ren View author

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CITE THIS ARTICLE Wold, L., Ceylan-isik, A. & Ren, J. Oxidative stress and stress signaling: menace of diabetic cardiomyopathy. _Acta Pharmacol Sin_ 26, 908–917 (2005).

https://doi.org/10.1111/j.1745-7254.2005.00146.x Download citation * Received: 02 March 2005 * Accepted: 13 April 2005 * Issue Date: 01 August 2005 * DOI:

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not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * diabetes * heart * cardiomyopathy * oxidative

stress * signal transduction