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ABSTRACT Non-progressive retinal lesions, observed in patients known to carry the gene for retinoblastoma, have in the past been called "spontaneous regression" of retinoblastoma.
This term suggests shrinkage of a malignant growth, perhaps in response to some host defence mechanism. On the basis of observations on 30 patients, we propose that the term
"retinoma" would be less presumptive and more suitable. Retinoma is clinically defined as a translucent, grey, elevated mass extending into the vitreous from the retina, frequently
associated with calcified foci and pigment-epithelium hyperplasia. The diagnosis of retinoma strongly suggests the presence of the retinoblastoma gene, necessitating genetic counselling and
frequent observation of the retinas in the individual and his offspring. We suggest that the same mutations can cause either retinoma or retinoblastoma: benign hyperplastic nodules or
retinoma when the mutations occur in relatively mature retinoblasts, and malignant retinoblastoma when the same mutations arise in immature retinoblasts. Access through your institution Buy
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OTHERS A HIGH-RISK RETINOBLASTOMA SUBTYPE WITH STEMNESS FEATURES, DEDIFFERENTIATED CONE STATES AND NEURONAL/GANGLION CELL GENE EXPRESSION Article Open access 22 September 2021 UNIQUE
COMBINATION OF CLINICAL FEATURES IN A LARGE COHORT OF 100 PATIENTS WITH RETINITIS PIGMENTOSA CAUSED BY _FAM161A_ MUTATIONS Article Open access 16 September 2020 RETINOBLASTOMA: EMERGING
CONCEPTS IN GENETICS, GLOBAL DISEASE BURDEN, CHEMOTHERAPY OUTCOMES, AND PSYCHOLOGICAL IMPACT Article 25 February 2022 Authors * B L Gallie View author publications You can also search for
this author inPubMed Google Scholar * R M Ellsworth View author publications You can also search for this author inPubMed Google Scholar * D H Abramson View author publications You can also
search for this author inPubMed Google Scholar * R A Phillips View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Gallie, B., Ellsworth, R., Abramson, D. _et al._ Retinoma: Spontaneous regression of retinoblastoma or benign manifestation of the mutation?.
_Br J Cancer_ 45, 513–521 (1982). https://doi.org/10.1038/bjc.1982.87 Download citation * Issue Date: 01 April 1982 * DOI: https://doi.org/10.1038/bjc.1982.87 SHARE THIS ARTICLE Anyone you
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