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ABSTRACT Because vanadate ion is a potent mitogen and accumulates in the gut of rodents fed vanadate supplements, effects of ammonium metavanadate in drinking water (10 ppm or 20 ppm) were
studied on the development of large bowel neoplasms in mice treated with 1,2-dimethylhydrazine (DMH) (20 mg kg-1 weekly for 20 weeks). In the colon at 30 weeks DMH treatment caused a 14%
increase in RNA content, an 18% increase in DNA content, and 33% deeper crypts. Vanadate at either 10 ppm or 20 ppm decreased RNA content by approximately 11%. Although vanadate increased
thymidine incorporation 210% to 550% compared with controls, it had no influence on the attack rate, incidence, or histological type of tumours induced by DMH. Access through your
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MOUSE MODELS Article Open access 04 March 2021 Authors * A N Kingsnorth View author publications You can also search for this author inPubMed Google Scholar * G M LaMuraglia View author
publications You can also search for this author inPubMed Google Scholar * J S Ross View author publications You can also search for this author inPubMed Google Scholar * R A Malt View
author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kingsnorth, A.,
LaMuraglia, G., Ross, J. _et al._ Vanadate supplements and 1,2-dimethylhydrazine induced colon cancer in mice: Increased thymidine incorporation without enhanced carcinogenesis. _Br J
Cancer_ 53, 683–686 (1986). https://doi.org/10.1038/bjc.1986.112 Download citation * Issue Date: 01 May 1986 * DOI: https://doi.org/10.1038/bjc.1986.112 SHARE THIS ARTICLE Anyone you share
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