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ABSTRACT The c-myc nuclear associated oncoprotein has been quantitated simultaneously with DNA in nuclei extracted from archival biopsies of uterine cervix neoplasia. The oncoprotein and DNA
were measured fluorimetrically in a flow cytometer using a mouse monoclonal antibody (MYC 1-6E10) and propidium iodide. Normal biopsies exhibited higher oncoprotein levels than carcinomas
(P less than 0.00001). Furthermore, the maximum fluorescence signal in the normal tissue occurred at a lower antibody concentration compared with tumour tissue. There was no correlation
between oncoprotein levels and histological grade, stage of disease, age of the patients or prognosis in the carcinomas. Aneuploidy, defined as a distinct second peak separate from the
diploid distribution, was not a significant feature. The c-myc oncoprotein nuclear content does not appear to be a prognostic indicator in carcinoma of the cervix from the results of these
studies but there is clearly diagnostic potential, particularly for automated analysis of cervical screening. Access through your institution Buy or subscribe This is a preview of
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IS ASSOCIATED WITH THE STAGE AND TUMOR IMMUNE INFILTRATION OF CERVICAL CANCER Article Open access 04 March 2025 HUMAN PAPILLOMAVIRUS INFECTION OF THE FALLOPIAN TUBE AS A POTENTIAL RISK
FACTOR FOR EPITHELIAL OVARIAN CANCER Article Open access 16 September 2024 DISTRIBUTION OF ESTROGEN RECEPTOR IN THE RABBIT CERVIX DURING PREGNANCY WITH SPECIAL REFERENCE TO STROMAL ELEMENTS:
AN IMMUNOHISTOCHEMICAL STUDY Article Open access 12 August 2020 Authors * P Hendy-Ibbs View author publications You can also search for this author inPubMed Google Scholar * H Cox View
author publications You can also search for this author inPubMed Google Scholar * GI Evan View author publications You can also search for this author inPubMed Google Scholar * JV Watson
View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hendy-Ibbs, P., Cox,
H., Evan, G. _et al._ Flow cytometric quantitation of DNA and c-_myc_ oncoprotein in archival biopsies of uterine cervix neoplasia. _Br J Cancer_ 55, 275–282 (1987).
https://doi.org/10.1038/bjc.1987.53 Download citation * Issue Date: 01 March 1987 * DOI: https://doi.org/10.1038/bjc.1987.53 SHARE THIS ARTICLE Anyone you share the following link with will
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