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ABSTRACT Dual photon absorptiometry (DPA) has been used to measure the effect of short and medium-term administration of tamoxifen on bone density in the axial skeleton of women with
mastalgia. This provided a unique opportunity to monitor the effect of this 'anti-oestrogenic' agent in predominantly premenopausal women, not suffering from malignancy. In
addition, plasma levels of calcium, phosphate, alkaline phosphatase and serum levels of oesteocalcin (GLA) have been assayed, both before and after 3 months of starting either tamoxifen or
placebo treatment. No significant alterations in bone density were seen. Osteocalcin, alkaline phosphatase and electrolytes were unchanged and there was no dose response observed in women
receiving either 10 mg or 20 mg of tamoxifen. Although possessing anti-oestrogenic properties, tamoxifen is also a partial agonist. Administration for the short periods does not measurably
influence spinal or femoral bone density and thus the agent can probably be given safely for the short-term treatment of mastalgia. Access through your institution Buy or subscribe This is a
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DENSITY IN WOMEN NEWLY DIAGNOSED WITH BREAST CANCER: A PROSPECTIVE COHORT STUDY Article Open access 17 February 2022 STEROID HORMONE LEVELS AND BONE MINERAL DENSITY IN WOMEN OVER 65 YEARS OF
AGE Article Open access 25 March 2023 BONE HEALTH IN NEWLY DIAGNOSED FEMALE BREAST CANCER PATIENTS IN CHINA: A CROSS-SECTIONAL STUDY Article Open access 01 February 2025 AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS * Department of Clinical Oncology, Guy's Hospital, London, UK IS Fentiman Authors * IS Fentiman View author publications You can also search for this author
inPubMed Google Scholar * M Caleffi View author publications You can also search for this author inPubMed Google Scholar * A Rodin View author publications You can also search for this
author inPubMed Google Scholar * B Murby View author publications You can also search for this author inPubMed Google Scholar * I Fogelman View author publications You can also search for
this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fentiman, I., Caleffi, M., Rodin, A. _et al._ Bone mineral content of
women receiving tamoxifen for mastalgia. _Br J Cancer_ 60, 262–264 (1989). https://doi.org/10.1038/bjc.1989.266 Download citation * Issue Date: 01 August 1989 * DOI:
https://doi.org/10.1038/bjc.1989.266 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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