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ABSTRACT We have examined the composition of the essential fatty acids in the plasma phospholipid fractions of 98 patients with histologically proven bladder cancer. These patients were
attending hospital for regular follow-up by check cystoscopy. Patients were divided into two groups, depending on the cystoscopic findings, of either active (tumour recurrence seen) or
inactive (no evidence of tumour recurrence) disease. Compared with a normal population, the plasma levels of most of the fatty acids, including arachidonic acid, were significantly lower in
the 98 cancer patients (P less than 0.001, t-test). We were unable, however, to demonstrate any significant differences (Mann-Whitney U-test) between the active and inactive disease groups.
Plasma levels of the essential fatty acids are abnormal in patients with bladder cancer; they do not help, however, to distinguish those patients with active disease from those with inactive
disease. This may arise because the deficit in essential fatty acids we have demonstrated is a predisposing factor for the development of bladder cancer rather than a metabolic consequence
of the tumour. Further studies are needed to establish the possible clinical role of measurement of essential fatty acids in patients with bladder carcinoma. Access through your institution
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OTHERS PLASMA LIPIDOMIC PROFILES OF KIDNEY, BREAST AND PROSTATE CANCER PATIENTS DIFFER FROM HEALTHY CONTROLS Article Open access 13 October 2021 DEPLETION OF ESSENTIAL FATTY ACIDS IN MUSCLE
IS ASSOCIATED WITH SHORTER SURVIVAL OF CANCER PATIENTS UNDERGOING SURGERY-PRELIMINARY REPORT Article Open access 26 November 2021 CIRCULATING AMINO ACIDS AND AMINO ACID-RELATED METABOLITES
AND RISK OF BREAST CANCER AMONG PREDOMINANTLY PREMENOPAUSAL WOMEN Article Open access 18 May 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Urology, Aberdeen Royal
Infirmary, UK S McClinton Authors * S McClinton View author publications You can also search for this author inPubMed Google Scholar * LEF Moffat View author publications You can also search
for this author inPubMed Google Scholar * DF Horrobin View author publications You can also search for this author inPubMed Google Scholar * MS Manku View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McClinton, S., Moffat, L., Horrobin, D. _et al._
Abnormalities of essential fatty acid distribution in the plasma phospholipids of patients with bladder cancer. _Br J Cancer_ 63, 314–316 (1991). https://doi.org/10.1038/bjc.1991.73 Download
citation * Issue Date: 01 February 1991 * DOI: https://doi.org/10.1038/bjc.1991.73 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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