ABSTRACT Fractionated TBI (FTBI) followed by allogeneic hematopoietic SCT results in donor engraftment and improves survival in children with high-risk hematologic malignancies. However,

acute toxicities (skin, lung and mucosa) are common after FTBI. Late complications include cataracts, endocrine dysfunction, sterility and impaired neurodevelopment. Instead of FTBI, we used

low-dose single fraction TBI (550 cGy) with CY as transplant conditioning for pediatric hematologic malignancies. GVHD prophylaxis included CYA and short-course MTX; methylprednisolone was

added for unrelated donor transplants. A total of 55 children in first (40%) or second remission and beyond (60%) underwent transplantation from BM (65%) or peripheral blood; 62% from

Non-relapse mortality was 6% thereafter. Graft rejection occurred in 2%. Three patients (5%) died of GVHD. The regimen was well tolerated even in heavily pretreated children and supported

donor cell engraftment; long-term follow up is in progress. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CURATIVE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOLLOWING REDUCED

TOXICITY CONDITIONING IN ADULTS WITH PRIMARY IMMUNODEFICIENCY Article 06 July 2022 REDUCED-TOXICITY MYELOABLATIVE CONDITIONING REGIMEN USING FLUDARABINE AND FULL DOSES OF INTRAVENOUS

BUSULFAN IN PEDIATRIC PATIENTS NOT ELIGIBLE FOR STANDARD MYELOABLATIVE CONDITIONING REGIMENS: RESULTS OF A MULTICENTER PROSPECTIVE PHASE 2 TRIAL Article 26 August 2022 REDUCED DOSE OF

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Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported in part by the National Institutes of Health under the Ruth L Kirschstein National Research Service Award T32 HD

007499 from the NICHD (TED). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Pediatric Hematology and Oncology, Department of Pediatrics, Bone Marrow Transplantation and Leukemia

Section, Washington University School of Medicine, Saint Louis, MO, USA T E Druley, R Hayashi, Y Barnes, S Witty, T Thomas & S Shenoy * Department of Radiation Oncology, Bone Marrow

Transplantation and Leukemia Section, Washington University School of Medicine, Saint Louis, MO, USA D B Mansur & E E Klein * Department of Biostatistics, Bone Marrow Transplantation and

Leukemia Section, Washington University School of Medicine, Saint Louis, MO, USA Q (Jean) Zhang & K Trinkaus * Division of Medical Oncology, Department of Internal Medicine, Bone Marrow

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CORRESPONDING AUTHOR Correspondence to S Shenoy. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Druley, T., Hayashi, R., Mansur, D. _et al._ Early

outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. _Bone Marrow Transplant_ 43, 307–314 (2009).

https://doi.org/10.1038/bmt.2008.327 Download citation * Received: 26 October 2007 * Revised: 17 August 2008 * Accepted: 21 August 2008 * Published: 17 November 2008 * Issue Date: February

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not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * hematopoietic cell transplant * children *

hematologic malignancies * single-dose TBI * outcomes