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Access through your institution Buy or subscribe Hypothyroidism and the presence of thyroid autoantibodies after SCT have been described earlier and are highly prevalent.1 (Autoimmune)
thyroid failure may be triggered by conditioning chemotherapy, TBI and graft-versus-host effect.2 However, data on thyrotoxicosis or thyroid hormone excess are scarce and limited to case
reports and case series.3, 4, 5, 6, 7 Between February 2006 and August 2007, 3 of 85 patients (3.5%) receiving SCT in our unit developed clinical thyrotoxicosis. Patient characteristics and
transplant modalities are shown in Table 1. The respective numbers of patients receiving an allo-SCT without TBI, an allo-SCT with TBI, an autologous SCT without TBI and an autologous SCT
with TBI within this time period were 20, 16, 47 and 2. Of the 36 patients receiving allo-SCT, 17 were treated with alemtuzumab (Campath-1H) and 19 without alemtuzumab. A significantly
higher incidence of thyrotoxicosis occurred in patients also receiving TBI as compared with patients not treated with TBI (3/18 patients (17%) compared with 0/65 patients (0%), respectively
(_P_<0.01, Fisher's exact test). There was no significant difference in the incidence of thyrotoxicosis between patients treated with alemtuzumab (Campath-1H) or not, either between
auto- or allo-SCT. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and
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which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Chemaitilly W,
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Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Internal Medicine, Division of Endocrinology, AZ St. Jan AV, Brugge, Belgium S
De Waele & A Van den Bruel * Department of Internal Medicine, Division of Hematology, AZ St. Jan AV, Brugge, Belgium D Selleslag * Department of Pathology, AZ St. Jan AV, Brugge, Belgium
I Van Den Berghe * Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium B Decallonne Authors * S De Waele View author publications You can also search for this author inPubMed
Google Scholar * A Van den Bruel View author publications You can also search for this author inPubMed Google Scholar * D Selleslag View author publications You can also search for this
author inPubMed Google Scholar * I Van Den Berghe View author publications You can also search for this author inPubMed Google Scholar * B Decallonne View author publications You can also
search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Van den Bruel. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE De
Waele, S., Van den Bruel, A., Selleslag, D. _et al._ Acute thyrotoxicosis after SCT. _Bone Marrow Transplant_ 43, 663–664 (2009). https://doi.org/10.1038/bmt.2008.374 Download citation *
Published: 17 November 2008 * Issue Date: April 2009 * DOI: https://doi.org/10.1038/bmt.2008.374 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this
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