ABSTRACT Intestinal transplant-associated microangiopathy (i-TAM) is an important complication after allogeneic hematopoietic SCT. From 1997 to 2006, 87 of 886 patients with diarrhea after

transplantation received colonoscopic biopsy. i-TAM, GVHD and CMV colitis were diagnosed histopathologically. The median duration from transplantation to the onset of diarrhea was 32 days

(range: 9–130 days) and that from the onset of diarrhea to biopsy was 12 days (range: 0–74 days). The median maximal amount of diarrhea was 2 l/day (range: 130–5600 ml/day).

Histopathological diagnosis included i-TAM (_n_=80), GVHD (_n_=26), CMV colitis (_n_=17) and nonspecific findings (_n_=2) with overlapping. Among 80 patients with i-TAM, abdominal pain was a

before and after diarrhea, respectively. In conclusion, i-TAM is a major complication presenting massive refractory diarrhea and abdominal pain, which causes NRM. Avoiding intensified

immunosuppression that damages vascular endothelium until the resolution of i-TAM may improve transplant outcome. Access through your institution Buy or subscribe This is a preview of

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2001; 53: 620–627. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Hematology, Japanese Red Cross Nagoya First Hospital,

Nagoya, Japan Y Inamoto, T Nishida, S Nishiwaki, T Oba, Y Kodera & K Miyamura * Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan Y

Inamoto, T Nishida, M Murata, M Yanada & T Naoe * Department of Pathology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan M Ito, M Fujino & N Hirabayashi * Department of

HSCT Data Management, Nagoya University School of Medicine, Nagoya, Japan R Suzuki * Department of Hematology, Meitetsu Hospital, Nagoya, Japan H Iida * Department of Hematology and

Oncology, Konan Kosei Hospital, Konan, Japan A Kohno & Y Morishita * Department of Hematology, Anjo Kosei Hospital, Anjo, Japan M Sawa * Department of Pathology, Nagoya University

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AUTHOR Correspondence to Y Inamoto. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Inamoto, Y., Ito, M., Suzuki, R. _et al._ Clinicopathological

manifestations and treatment of intestinal transplant-associated microangiopathy. _Bone Marrow Transplant_ 44, 43–49 (2009). https://doi.org/10.1038/bmt.2008.419 Download citation *

Received: 01 July 2008 * Revised: 17 November 2008 * Accepted: 21 November 2008 * Published: 12 January 2009 * Issue Date: July 2009 * DOI: https://doi.org/10.1038/bmt.2008.419 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * allogeneic transplantation * microangiopathy * intestinal * GVHD * pathology