ABSTRACT Healthy cardiac autonomic functioning (CAF) is essential for maintaining homeostasis in response to the environmental demands of everyday life. Impaired CAF is associated with

higher morbidity and higher mortality. To explore CAF in survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) 1–10 years after transplant (median=4.3 years), an

ambulatory assessment was performed with 104 patients, and 45 age- and gender-matched healthy controls. Heart rate (HR) and respiratory sinus arrhythmia (RSA, that is, high-frequency HR

variability) were measured in a laboratory setting and during a 12-hour naturalistic period of daily life. Cancer-related fatigue was assessed by the Functional Assessment of Chronic Illness

_d_=0.88) and mean RSA magnitude lower (_P_<0.001, _d_=0.69) among patients, compared with controls. Severely fatigued patients showed higher HR and lower parasympathetic cardiac control

than non-fatigued patients (HR: _P_=0.02, _d_=0.47; RSA: _P_=0.02, _d_=0.72), and this was unrelated to fitness. These findings may have important implications for predicting long-term

treatment outcome and consequences for routine post-HSCT care. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS REDUCED PREFRONTAL CORTEX AND SYMPATHETIC NERVOUS SYSTEM ACTIVITY CORRELATE WITH

FATIGUE AFTER AHSCT Article Open access 04 December 2021 REDUCED CARDIOVASCULAR RESERVE CAPACITY IN LONG-TERM ALLOGENEIC STEM CELL TRANSPLANT SURVIVORS Article Open access 06 February 2023

MHEALTH SYSTEM (ATOPE+) TO SUPPORT EXERCISE PRESCRIPTION IN BREAST CANCER SURVIVORS: A RELIABILITY AND VALIDITY, CROSS-SECTIONAL OBSERVATIONAL STUDY (ATOPE STUDY) Article Open access 08

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Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We thank the Swiss Cancer League for funding this study (grant no.: KLS-02038-02-2007). Special thanks to the nurses and

physicians of the Zellersatzambulatorium of the Hematology Department of University Hospital Basel for great collaboration and logistical support. Above all, we thank all study participants.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychosomatic Medicine, Division of Internal Medicine, University Hospital Basel, Basel, Switzerland G Deuring, A Kiss & P

Grossman * Department of Hematology, Division of Internal Medicine, University Hospital Basel, Basel, Switzerland J P Halter & J R Passweg * Department of Forensic Psychiatry, University

Psychiatric Clinics, Basel, Switzerland G Deuring Authors * G Deuring View author publications You can also search for this author inPubMed Google Scholar * A Kiss View author publications

You can also search for this author inPubMed Google Scholar * J P Halter View author publications You can also search for this author inPubMed Google Scholar * J R Passweg View author

publications You can also search for this author inPubMed Google Scholar * P Grossman View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHORS Correspondence to G Deuring or P Grossman. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION Supplementary Information

accompanies this paper on Bone Marrow Transplantation website SUPPLEMENTARY INFORMATION SUPPLEMENTARY TABLE 1 (DOC 34 KB) SUPPLEMENTARY TABLE 2 (DOC 29 KB) SUPPLEMENTARY TABLE 3 (DOC 31 KB)

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Deuring, G., Kiss, A., Halter, J. _et al._ Cardiac autonomic functioning is impaired among allogeneic

hematopoietic stem cell transplantation survivors: a controlled study. _Bone Marrow Transplant_ 52, 66–72 (2017). https://doi.org/10.1038/bmt.2016.176 Download citation * Received: 04

January 2016 * Revised: 21 April 2016 * Accepted: 11 May 2016 * Published: 04 July 2016 * Issue Date: January 2017 * DOI: https://doi.org/10.1038/bmt.2016.176 SHARE THIS ARTICLE Anyone you

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