Dna strands show symmetry in damage tolerance but asymmetries in repair efficiency

Dna strands show symmetry in damage tolerance but asymmetries in repair efficiency

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* RESEARCH BRIEFINGS * 07 August 2024 The two strands of DNA, although chemically equivalent, are replicated and repaired asymmetrically. Insights into the persistence of DNA damage show how


strand-specific interactions shape the genome-wide distribution of mutations, including the unexpected symmetry of mutations arising in the DNA strands during replication.