ABSTRACT BACKGROUND AND OBJECTIVES: The pathogenesis of the metabolic syndrome (MetS) is not well understood. This review is based on the hypothesis that both traditional and emerging risk

factors act through adiponectin. SUBJECTS AND METHODS: We conducted a search of the literature using prominent electronic databases and search terms that included in combination:

adiponectin, diet, dietary patterns, exercise, metabolic rate, MetS and testosterone. Articles were restricted to studies conducted on adult humans, reported in English and within the time

period 2000–2012. RESULTS AND CONCLUSIONS: Both traditional and emerging risk factors associated with the MetS show some evidence of exerting their influence through adiponectin.

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_et al_. Adiponectin acts in the brain to decrease body weight. _Nat Med_ 2004; 10: 524–529. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Discipline of Nutrition and Dietetics, School of Public Health, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia. E K Calton, V S Miller & M J Soares

Authors * E K Calton View author publications You can also search for this author inPubMed Google Scholar * V S Miller View author publications You can also search for this author inPubMed 

Google Scholar * M J Soares View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M J Soares. ETHICS DECLARATIONS

COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION AUTHOR CONTRIBUTIONS EKC conducted the search, collated the information and wrote the first draft. VM

critically revewied and co-wrote the mansucript. MJS planned the review, cross-checked information and co-wrote the manuscript. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Calton, E., Miller, V. & Soares, M. Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?. _Eur J Clin Nutr_ 67,

485–491 (2013). https://doi.org/10.1038/ejcn.2013.1 Download citation * Received: 06 August 2012 * Revised: 12 December 2012 * Accepted: 26 December 2012 * Published: 30 January 2013 * Issue

Date: May 2013 * DOI: https://doi.org/10.1038/ejcn.2013.1 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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* diet * vitamin D * basal metabolic rate * mitochondria