ABSTRACT IgG has a crucial role in humoral immune response. Serum IgG level is mainly determined under genetic control. To explore the genetic influence on serum IgG levels, a two-stage

genome-wide association study (GWAS) was performed in a healthy Chinese population of 3495 men, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the

second stage. Three single-nucleotide polymorphisms (SNPs) located in _TNFRSF13B_ on 17p11.2 or nearby were significantly associated with IgG level: rs4792800 in the intron (combined

_P_-value=1.45 × 10−12), rs12603708 in the intron (combined _P_-value=1.82 × 10−8) and rs3751987 at ∼65 kb downstream of the 5′-UTR region of _TNFRSF13B_ (combined _P_-value=3.67 × 10−9).

transmembrane activator, calcium modulator and cyclophilin ligand interactor encoded by _TNFRSF13B_. Access through your institution Buy or subscribe This is a preview of subscription

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INCREASES FLT3 LIGAND LEVEL AND RISK OF AUTOIMMUNE THYROID DISEASE Article 24 June 2020 GENOME-WIDE ASSOCIATION STUDY FOR CIRCULATING FIBROBLAST GROWTH FACTOR 21 AND 23 Article Open access

03 September 2020 GENOME-WIDE ASSOCIATION STUDY IDENTIFIES FIVE RISK LOCI FOR PERNICIOUS ANEMIA Article Open access 18 June 2021 CHANGE HISTORY * _ 30 AUGUST 2012 This article has been

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genome-wide association studies. _Nat Genet_ 2006; 38: 904–909. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We express our sincere thanks to the local research teams

from Fangchenggang First People’s Hospital, Fangchenggang, China, for the recruitment of study subjects. We thank Y-M Wu, Y Sun and Z-X Li, for their assistance in the study recruitment. We

thank X-W Zou, H-C Zheng and O Li at the Genergy Biotechnology (Shanghai) Co., Ltd, for their assistance in the genotyping. Finally, we thank all study subjects for participating in the

study. The work described in this article is supported by grants from the National Natural Science Foundation of China (Grant no. 30945204) and the Provincial departments of Finance and

Education, Guangxi Zhuang Autonomous Region, China (Grant no. 2009GJCJ150). AUTHOR INFORMATION Author notes * M Liao, F Ye, B Zhang, L Huang and Q Xiao: These authors contributed equally to

this work. AUTHORS AND AFFILIATIONS * Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, China M Liao, M Qin, L Mo, Y Gao, Z Lu, C Wu, Y

Zhang & Z Mo * Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China M Liao, F Ye, B Zhang, L Huang, Q Xiao, A Tan, Y Gao, Z Lu, C Wu, Y Zhang, H

Zhang, X Qin, Y Hu, X Yang & Z Mo * Center for Metabolic Disease and Diabetes, First Affiliated Hospital of Guangxi Medical University, Nanning, China A Tan * Department of Occupational

Health and Environmental Health, School of Public Health of Guangxi Medical University, Nanning, China H Zhang & X Yang * Department of Clinical Laboratory, First Affiliated Hospital of

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_et al._ Genome-wide association study identifies common variants at _TNFRSF13B_ associated with IgG level in a healthy Chinese male population. _Genes Immun_ 13, 509–513 (2012).

https://doi.org/10.1038/gene.2012.26 Download citation * Received: 16 March 2012 * Revised: 01 May 2012 * Accepted: 04 May 2012 * Published: 07 June 2012 * Issue Date: September 2012 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * IgG * genome-wide association studies * _TNFRSF13B_ *

TACI * smoking