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ABSTRACT Langerhans cells (LCs) are bone marrow-derived immature skin-residential dendritic cells (DCs) with a life cycle distinct from that of other types of DCs. The mechanisms involved in
LC homeostasis and immunological functions are still not clear. MicroRNAs (miRNAs) are a class of short noncoding RNAs that regulate gene expression through either translational repression
or mRNA degradation. A recent study showed that specific deletion of total miRNAs in DCs affects the homeostasis and function of only LCs, but not of other types of DCs. The roles of
specific individual miRNA in LC development are still lacking. The miRNA miR-17-92 class, encoding miR-17, miR-18, miR-19a, miR-19b, miR-20 and miR-92, plays a very important role in B- and
T-cell development and function. Here, we first report that epidermal LCs highly express the miR-17-92 class compared with spleen naive T cells. To further characterize the role of miR-17-92
in LC development, we generated LC-specific miR-17-92 knockout and knock-in mice. Interestingly, LC-specific gain- and loss-of-function of miR-17-92 cluster did not significantly change LC
homeostasis, maturation ability, antigen capture and migration to draining lymph nodes. Thus, the miR-17-92 cluster may be functionally redundant and not critically required for LC
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subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MIR-369-3P MODULATES INDUCIBLE NITRIC OXIDE SYNTHASE AND IS INVOLVED IN REGULATION OF CHRONIC
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SKIN-RESIDENT INNATE LYMPHOID CELLS CONVERGE ON A PATHOGENIC EFFECTOR STATE Article 03 February 2021 REFERENCES * Zhou L, Park JJ, Zheng Q, Dong Z, Mi Q . MicroRNAs are key regulators
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laboratories for their advice and encouragement. This work was supported by grants from the National Institutes of Health Grant 1R21AR059976 and Henry Ford Health System Start-up Grant for
the Immunology Program (T71016 and T71017). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Henry Ford Immunology Program, Henry Ford Hospital, Detroit, MI, USA L Zhou, R-Q Qi, M Liu, Y-P Xu,
G Li, M Weiland & Q-S Mi * Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA L Zhou, R-Q Qi, M Liu, Y-P Xu, G Li, M Weiland & Q-S Mi * Department of Internal Medicine,
Henry Ford Hospital, Detroit, MI, USA L Zhou & Q-S Mi * Department of Dermatology and Center for Immunology, University of Minnesota, Minneapolis, MN, USA D H Kaplan Authors * L Zhou
View author publications You can also search for this author inPubMed Google Scholar * R-Q Qi View author publications You can also search for this author inPubMed Google Scholar * M Liu
View author publications You can also search for this author inPubMed Google Scholar * Y-P Xu View author publications You can also search for this author inPubMed Google Scholar * G Li View
author publications You can also search for this author inPubMed Google Scholar * M Weiland View author publications You can also search for this author inPubMed Google Scholar * D H Kaplan
View author publications You can also search for this author inPubMed Google Scholar * Q-S Mi View author publications You can also search for this author inPubMed Google Scholar
CORRESPONDING AUTHORS Correspondence to L Zhou or Q-S Mi. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE Zhou, L., Qi, RQ., Liu, M. _et al._ microRNA miR-17-92 cluster is highly expressed in epidermal Langerhans cells but not required for its development.
_Genes Immun_ 15, 57–61 (2014). https://doi.org/10.1038/gene.2013.61 Download citation * Received: 15 August 2013 * Revised: 23 October 2013 * Accepted: 24 October 2013 * Published: 28
November 2013 * Issue Date: January 2014 * DOI: https://doi.org/10.1038/gene.2013.61 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * miRNAs *
Langerhans cells * skin * miR-17-92 * knockout * knock-in