The expected distribution of marker-linked quantitative effects in crosses between inbred lines

The expected distribution of marker-linked quantitative effects in crosses between inbred lines

Play all audios:

Loading...

SUMMARY The _a priori_ theoretical distribution of marker-linked quantitative effects in crosses involving inbred lines, and the number of quantitative loci contributing to such effects was obtained by numerical analysis, and examined as a function of the number and effects of the quantitative loci differentiating the lines, the location of the marker relative to the chromosome ends, and the mapping function. Over a wide range of assumptions it was found that the probability that a given marker will have an associated linked quantitative effect equal in magnitude to 0·2 phenotypic standard deviations or greater is of the order of 0·10 or more. In most of these cases it can be expected that the marker-linked effects will be due to one, or at the most two, quantitative loci in the vicinity of the marker. SIMILAR CONTENT BEING VIEWED BY OTHERS TEMPORAL AND GENOMIC ANALYSIS OF ADDITIVE GENETIC VARIANCE IN BREEDING PROGRAMMES Article Open access 15 December 2021 RANK-INVARIANT ESTIMATION OF INBREEDING COEFFICIENTS Article Open access 25 November 2021 DETECTING PURGING OF INBREEDING DEPRESSION BY A SLOW RATE OF INBREEDING FOR VARIOUS TRAITS: THE IMPACT OF ENVIRONMENTAL AND EXPERIMENTAL CONDITIONS Article 26 April 2021 ARTICLE PDF REFERENCES * Chai, C K. 1975. Genes associated with leukocyte production in mice. _J Heredity_, 66, 301–308. Article  CAS  Google Scholar  * Falconer, D S. 1960. _Introduction to Quantitative Genetics_. The Ronald Press Co., New York. Google Scholar  * Fasoulas, A C, and Allard, R W. 1962. Non-allelic gene interactions in the inheritance of quantitative characters in barley. _Genetics_, 47, 899–907. CAS  PubMed  PubMed Central  Google Scholar  * Law, C N. 1967. The location of genetic factors controllong a number of quantitative characters in wheat. _Genetics_, 56, 445–461. CAS  PubMed  PubMed Central  Google Scholar  * Lieberman, R, Stiffel, C, Asofsky, R, Mouton, D, Biozzi, G, and Benaceraff, B. 1972. Genetic factors controlling anti-sheep erythrocyte antibody response and immunoglobulin synthesis in backcross and F2 progeny of mice genetically selected for “high” or “ low ” anibody synthesis. _J Exp Med_, 136, 790–798. Article  CAS  PubMed  PubMed Central  Google Scholar  * Rasmusson, J M. 1935. Studies on the inheritance of quantitative characters in _Pisum_: I. Preliminary note on the genetics of flowering. _Hereditas_, 20, 161–180. Article  Google Scholar  * Sax, K. 1923. The association of size differences with seed-coat pattern and pigmentation in _Phaseolus vulgaris_. _Genetics_, 8, 552–560. CAS  PubMed  PubMed Central  Google Scholar  * Soller, M, Genizi, A, and Brody, T. 1976. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. _Theoretical and Applied Genetics_, 47, 35–39. Article  CAS  PubMed  Google Scholar  * Soller, M, and Plotkin-Hazan, J. 1978. The use of marker alleles for the introgression of linked quantitative alleles. _Theoretical and Applied Genetics_, 51, 133–137. Article  Google Scholar  * Stahl, F W. 1969. _The Mechanics of Inheritance_, 2nd Edition. Prentice-Hall, Inc., Englewood Cliffs, New Jersey. Google Scholar  * Strickberger, M. 1968. _Genetics_, 2nd Edition. Macmillan Co., New York. Google Scholar  * Thoday, J M. 1961. Location of polygenes. _Nature_, 191, 368–370. Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Genetics, The Hebrew University, Jerusalem, Israel M Soller & T Brody * Division of Statistics and Experimental Design, Israel Agricultural Research Organisation, Bet Dagan, Israel A Genizi Authors * M Soller View author publications You can also search for this author inPubMed Google Scholar * T Brody View author publications You can also search for this author inPubMed Google Scholar * A Genizi View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Soller, M., Brody, T. & Genizi, A. The expected distribution of marker-linked quantitative effects in crosses between inbred lines. _Heredity_ 43, 179–190 (1979). https://doi.org/10.1038/hdy.1979.73 Download citation * Received: 22 March 1979 * Issue Date: 01 October 1979 * DOI: https://doi.org/10.1038/hdy.1979.73 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

SUMMARY The _a priori_ theoretical distribution of marker-linked quantitative effects in crosses involving inbred lines, and the number of quantitative loci contributing to such effects was


obtained by numerical analysis, and examined as a function of the number and effects of the quantitative loci differentiating the lines, the location of the marker relative to the chromosome


ends, and the mapping function. Over a wide range of assumptions it was found that the probability that a given marker will have an associated linked quantitative effect equal in magnitude


to 0·2 phenotypic standard deviations or greater is of the order of 0·10 or more. In most of these cases it can be expected that the marker-linked effects will be due to one, or at the most


two, quantitative loci in the vicinity of the marker. SIMILAR CONTENT BEING VIEWED BY OTHERS TEMPORAL AND GENOMIC ANALYSIS OF ADDITIVE GENETIC VARIANCE IN BREEDING PROGRAMMES Article Open


access 15 December 2021 RANK-INVARIANT ESTIMATION OF INBREEDING COEFFICIENTS Article Open access 25 November 2021 DETECTING PURGING OF INBREEDING DEPRESSION BY A SLOW RATE OF INBREEDING FOR


VARIOUS TRAITS: THE IMPACT OF ENVIRONMENTAL AND EXPERIMENTAL CONDITIONS Article 26 April 2021 ARTICLE PDF REFERENCES * Chai, C K. 1975. Genes associated with leukocyte production in mice. _J


Heredity_, 66, 301–308. Article  CAS  Google Scholar  * Falconer, D S. 1960. _Introduction to Quantitative Genetics_. The Ronald Press Co., New York. Google Scholar  * Fasoulas, A C, and


Allard, R W. 1962. Non-allelic gene interactions in the inheritance of quantitative characters in barley. _Genetics_, 47, 899–907. CAS  PubMed  PubMed Central  Google Scholar  * Law, C N.


1967. The location of genetic factors controllong a number of quantitative characters in wheat. _Genetics_, 56, 445–461. CAS  PubMed  PubMed Central  Google Scholar  * Lieberman, R, Stiffel,


C, Asofsky, R, Mouton, D, Biozzi, G, and Benaceraff, B. 1972. Genetic factors controlling anti-sheep erythrocyte antibody response and immunoglobulin synthesis in backcross and F2 progeny


of mice genetically selected for “high” or “ low ” anibody synthesis. _J Exp Med_, 136, 790–798. Article  CAS  PubMed  PubMed Central  Google Scholar  * Rasmusson, J M. 1935. Studies on the


inheritance of quantitative characters in _Pisum_: I. Preliminary note on the genetics of flowering. _Hereditas_, 20, 161–180. Article  Google Scholar  * Sax, K. 1923. The association of


size differences with seed-coat pattern and pigmentation in _Phaseolus vulgaris_. _Genetics_, 8, 552–560. CAS  PubMed  PubMed Central  Google Scholar  * Soller, M, Genizi, A, and Brody, T.


1976. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. _Theoretical and Applied Genetics_, 47,


35–39. Article  CAS  PubMed  Google Scholar  * Soller, M, and Plotkin-Hazan, J. 1978. The use of marker alleles for the introgression of linked quantitative alleles. _Theoretical and Applied


Genetics_, 51, 133–137. Article  Google Scholar  * Stahl, F W. 1969. _The Mechanics of Inheritance_, 2nd Edition. Prentice-Hall, Inc., Englewood Cliffs, New Jersey. Google Scholar  *


Strickberger, M. 1968. _Genetics_, 2nd Edition. Macmillan Co., New York. Google Scholar  * Thoday, J M. 1961. Location of polygenes. _Nature_, 191, 368–370. Article  Google Scholar  Download


references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Genetics, The Hebrew University, Jerusalem, Israel M Soller & T Brody * Division of Statistics and Experimental


Design, Israel Agricultural Research Organisation, Bet Dagan, Israel A Genizi Authors * M Soller View author publications You can also search for this author inPubMed Google Scholar * T


Brody View author publications You can also search for this author inPubMed Google Scholar * A Genizi View author publications You can also search for this author inPubMed Google Scholar


RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Soller, M., Brody, T. & Genizi, A. The expected distribution of marker-linked quantitative effects in


crosses between inbred lines. _Heredity_ 43, 179–190 (1979). https://doi.org/10.1038/hdy.1979.73 Download citation * Received: 22 March 1979 * Issue Date: 01 October 1979 * DOI:


https://doi.org/10.1038/hdy.1979.73 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently


available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative