ABSTRACT BACKGROUND/OBJECTIVES: Mounting evidence supports a link between circadian disruption and metabolic disease. Humans with circadian disruption (for example, night-shift workers) have

an increased risk of obesity and cardiometabolic diseases compared with the non-disrupted population. However, it is unclear whether the obesity and obesity-related disorders associated

with circadian disruption respond to therapeutic treatments as well as individuals with other types of obesity. SUBJECTS/METHODS: Here, we test the effectiveness of the commonly used

bariatric surgical procedure, Vertical Sleeve Gastrectomy (VSG), in mouse models of genetic and environmental circadian disruption. RESULTS: VSG led to a reduction in body weight and fat

(_P_<0.05). CONCLUSIONS: Together these data demonstrate that VSG is an effective treatment for the obesity associated with circadian disruption, and that the potent effects of bariatric

surgery are orthogonal to circadian biology. However, as the effects of bariatric surgery are independent of circadian disruption, VSG cannot be considered a cure for circadian disruption.

These data have important implications for circadian-disrupted obese patients. Moreover, these results reveal new information about the metabolic pathways governing the effects of bariatric

surgery as well as of circadian disruption. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CHRONIC CIRCADIAN DISRUPTION ALTERS CARDIAC FUNCTION AND GLUCOSE REGULATION IN MICE Article

Open access 13 May 2025 TIME-OF-DAY DEFINES NAD+ EFFICACY TO TREAT DIET-INDUCED METABOLIC DISEASE BY SYNCHRONIZING THE HEPATIC CLOCK IN MICE Article Open access 27 March 2023 SYNCHRONIZATION

OF THE CIRCADIAN CLOCK BY TIME-RESTRICTED FEEDING WITH PROGRESSIVE INCREASING CALORIE INTAKE. RESEMBLANCES AND DIFFERENCES REGARDING A SUSTAINED HYPOCALORIC RESTRICTION Article Open access

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Vitaterna MH _et al_. Circadian disorganization alters intestinal microbiota. _PLoS One_ 2014; 9: e97500. Article  Google Scholar  Download references ACKNOWLEDGEMENTS Grant Support: This

work was supported by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (F32 DK097867-01, D.Arble; DK082480-01, D.Sandoval; and R01

DK093848-01, R.Seeley). AUTHOR CONTRIBUTIONS DMA designed and performed experiments, analyzed data and wrote the manuscript. DAS, FWT, SCW and RJS contributed to experimental design and

edited the manuscript. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Surgery, University of Michigan, Ann Arbor, MI, USA D M Arble, D A Sandoval & R J Seeley * Neurobiology

and Neurology, Northwestern University, Evanston, IL, USA F W Turek * Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA S C Woods Authors * D M Arble

View author publications You can also search for this author inPubMed Google Scholar * D A Sandoval View author publications You can also search for this author inPubMed Google Scholar * F W

Turek View author publications You can also search for this author inPubMed Google Scholar * S C Woods View author publications You can also search for this author inPubMed Google Scholar *

R J Seeley View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to R J Seeley. ETHICS DECLARATIONS COMPETING INTERESTS

DMA, FWT and SCW have no conflicts to declare. DAS receives funding from Ethicon Endo-Surgery, Novo Nordisk and Boehringer Ingelheim International. RJS receives funding from Ethicon

Endo-Surgery, Ablaris Therapeutics, Inc., Novo Nordisk, Novartis, Angiochem, Eisai, Forest Pharmaceuticals, Givaudan, Zealand Pharmaceuticals and Boehringer Ingelheim International.

ADDITIONAL INFORMATION Supplementary Information accompanies this paper on International Journal of Obesity website SUPPLEMENTARY INFORMATION SUPPLEMENTARY FIGURE 1 (JPG 745 KB)

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Turek, F. _et al._ Metabolic effects of bariatric surgery in mouse models of circadian disruption. _Int J Obes_ 39, 1310–1318 (2015). https://doi.org/10.1038/ijo.2015.54 Download citation *

Received: 03 December 2014 * Revised: 14 March 2015 * Accepted: 04 April 2015 * Published: 14 April 2015 * Issue Date: August 2015 * DOI: https://doi.org/10.1038/ijo.2015.54 SHARE THIS

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