ABSTRACT Fine particulate matter (PM2.5) in air pollution, primarily from combustion sources, is recognized as an important risk factor for cardiovascular events but studies of workplace

PM2.5 exposure are rare. We conducted a prospective study of exposure to PM2.5 and incidence of ischemic heart disease (IHD) in a cohort of 11,966 US aluminum workers. Incident IHD was

identified from medical claims data from 1998 to 2008. Quantitative metrics were developed for recent exposure (within the last year) and cumulative exposure; however, we emphasize recent

exposure in the absence of interpretable work histories before follow-up. IHD was modestly associated with recent PM2.5 overall. In analysis restricted to recent exposures estimated with the

differences in exposure composition or healthy worker survivor effect. These results are consistent with the air pollution and cigarette smoke literature; recent exposure to PM2.5 in the

workplace appears to increase the risk of IHD incidence. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS SHORT AND LONG TERM EXPOSURE TO AIR POLLUTION INCREASES THE RISK OF ISCHEMIC

HEART DISEASE Article Open access 03 March 2021 RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN A LARGE COHORT OF ONTARIO, CANADA WORKERS Article Open access 16 April 2024 ECOLOGICAL STUDY

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references ACKNOWLEDGEMENTS This work was supported by National Institutes of Health, Institute of Aging (R01 AG026291-01) and Center for Disease Control and Prevention, National Institute

of Occupational Safety and Health (R01OH009939-01) and by Alcoa. NIA Data Sharing: As an alternative to providing a de-identified data set to the public domain, we allow access for the

purpose of re-analyses or appropriate “follow-on” analyses by any qualified investigator willing to sign a contractual covenant with the host Institution limiting use of data to a specific

agreed upon purpose and observing the same restrictions as are limited in our contract with Alcoa, such as 60-day manuscript review for compliance purposes. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Environmental Health Science, School of Public Health, University of California, Berkeley, California, USA Sadie Costello, Daniel M Brown, Elizabeth M Noth, S Katharine

Hammond & Ellen A Eisen * Occupational and Environmental Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA Linda Cantley, Martin D Slade & Baylah

Tessier-Sherman * Department of Internal Medicine, Stanford University, Stanford, California, USA Mark R Cullen Authors * Sadie Costello View author publications You can also search for this

author inPubMed Google Scholar * Daniel M Brown View author publications You can also search for this author inPubMed Google Scholar * Elizabeth M Noth View author publications You can also

search for this author inPubMed Google Scholar * Linda Cantley View author publications You can also search for this author inPubMed Google Scholar * Martin D Slade View author publications

You can also search for this author inPubMed Google Scholar * Baylah Tessier-Sherman View author publications You can also search for this author inPubMed Google Scholar * S Katharine

Hammond View author publications You can also search for this author inPubMed Google Scholar * Ellen A Eisen View author publications You can also search for this author inPubMed Google

Scholar * Mark R Cullen View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sadie Costello. ETHICS DECLARATIONS

COMPETING INTERESTS Drs Costello, Brown, Noth and Eisen do not have any conflicts of interest to declare. Ms Cantley and Ms Tessier-Sherman receive salary support from Alcoa, Inc through

contracts with Yale University. Dr Cullen receives salary support from Alcoa, Inc through contracts with Stanford University. Dr Hammond receives compensation as a member of the scientific

advisory board for Alcoa, Inc and has also consulted on exposure assessment and received compensation. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Costello, S., Brown, D., Noth, E. _et al._ Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort. _J Expo Sci Environ Epidemiol_ 24,

82–88 (2014). https://doi.org/10.1038/jes.2013.47 Download citation * Received: 15 February 2013 * Accepted: 20 June 2013 * Published: 28 August 2013 * Issue Date: January 2014 * DOI:

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available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * occupational epidemiology * particulate matter * heart disease