SUMMARY Chromosome studies were carried out in 110 patients with cleft lip and/or cleft palate. Major chromosome abnormalities were found in four cases (3.6%). They included two cases of 46,

XX, 4p−, one case of 47,XY, +21 and one case of 46,XX, inv(1) (p32q12). The incidence of chromosome abnormalities in patients with cleft lip and/or cleft palate was about 5.2 times higher

than that in newborn children. SIMILAR CONTENT BEING VIEWED BY OTHERS MOLECULAR INVESTIGATION IN INDIVIDUALS WITH OROFACIAL CLEFTS AND MICROPHTHALMIA-ANOPHTHALMIA-COLOBOMA SPECTRUM Article

06 November 2023 DEEP OROFACIAL PHENOTYPING OF POPULATION-BASED INFANTS WITH ISOLATED CLEFT LIP AND ISOLATED CLEFT PALATE Article Open access 10 December 2020 GENETICS AND OROFACIAL CLEFTS:

18: 225–230. Google Scholar  * Chang, T., Coursin, D. B., and Hauck, M. 1970. Leukocyte chromosome study of 22 families with cleft lip and/or cleft palate members._Cleft Palate J._ 7:

402–410. CAS  PubMed  Google Scholar  * Friedrich, U. and Nielsen, J. 1973. Chromosome studies in 5049 consecutive newborn children._Clin. Genet._ 4: 333–343. Article  CAS  PubMed  Google

Scholar  * Gropp, A., Jussen, A., and Odunjo, F. 1964. Near-triploid chromosome constitution in epithelialcell culture of palatal mucosa from a case of cleft palate._Lancet_ I: 1167. Article

  Google Scholar  * Hirakawa, M. and Adachi, K. 1970. Cytogenetic studies in 100 patients with cleft lip and cleft palate._Kyushu Dental Soc._ 24: 73–85. Google Scholar  * Jackson, J. F.

1966. Chromosomes in cleft-palate tissues._Lancet_ I: 1156. Article  Google Scholar  * MacMahon, B. and McKeown, T. 1953. The incidence of harelip and cleft palate related to birth rank and

maternal age._Amer. J. Hum. Genet._ 5: 176–183. CAS  PubMed  Google Scholar  * Makino, S. 1964. Chromosomal studies in normal human subjects and 300 cases of congenital disorders._Cytologia_

29: 125–150. Article  Google Scholar  * Muramoto, J., Aya, T., and Sasaki, M. 1966. A chromosome study of patients with cleft lip and cleft palate based on lesion biopsies in culture._Jap.

J. Human Genet._ 11: 31–35. CAS  Google Scholar  * Sasaki, M., Azumi, J., and Igarashi, T. 1974a. Chromosome surveys in patients with cleft lip and/or cleft palate, (I)._Chrom. Infor. Ser._

17: 15–16. Google Scholar  * Sasaki, M., Azumi, J., and Igarashi, T. 1974b. Chromosome surveys in patients with cleft lip and/or cleft palate, (II)._Chrom. Infor. Ser._ 17: 16–18. Google

Scholar  * Sasaki, M., Azumi, J., and Komatsu, Y. 1975. Chromosome surveys in patients with cleft lip and/or cleft palate, (III)._Chrom. Infor. Ser._ 18: 8–10. Google Scholar  * Soukup, S.

and Warkany, J. 1966. Chromosomes in cleft-palate tissues._Lancet_ I: 492–493. Article  Google Scholar  * Subrt, I., Cervenka, J., and Krecek, M. 1966. Cytogenetic study of cleft lip and

palate._Cleft Palate J._ 3: 362–367. CAS  PubMed  Google Scholar  * Surina, I. and Tajmirova, O. 1968. Cytogenetic study of patients with cleft lip and palate._Acta Chir. Plast._ 10:

177–180. CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION Author notes * Jun-ichi Azumi & Gen-iku Kohama Present address: Department of Human Genetics, National

Institute of Genetics, Mishima, Japan AUTHORS AND AFFILIATIONS * Department of Oral Surgery, Sapporo Medical College, Sapporo, Japan Gen-iku Kohama * Department of Stomatology, Nagasaki

University School of Medicine, Nagasaki, Japan Jun-ichi Azumi & Motomasa Sasaki Authors * Jun-ichi Azumi View author publications You can also search for this author inPubMed Google

Scholar * Gen-iku Kohama View author publications You can also search for this author inPubMed Google Scholar * Motomasa Sasaki View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Azumi, Ji., Kohama, Gi. & Sasaki, M. Cytogenetic studies in patients with

cleft lip and/or cleft palate (IV). _Jap J Human Genet_ 23, 161–166 (1978). https://doi.org/10.1007/BF02001798 Download citation * Received: 25 January 1978 * Published: 01 June 1978 * Issue

Date: June 1978 * DOI: https://doi.org/10.1007/BF02001798 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Chromosome Abnormality * Cleft

Palate * Chromosome Study * Cleave Palate * Newborn Child