Perinatal characteristics and parents' perspective of health status of nicu graduates born at term

Perinatal characteristics and parents' perspective of health status of nicu graduates born at term

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ABSTRACT OBJECTIVE: Long-term outcomes of preterm infants have been extensively studied, but few studies have examined long-term outcomes of term infants who require neonatal intensive care unit (NICU). Our objectives were to assess perinatal characteristics and health status of preschool age term babies using data from a population-based study of NICU graduates. STUDY DESIGN: Retrospective cross-sectional survey. All babies were born in 1996 to 1997 in BC (Canada). The Health Status Classification System Preschool (HSCS-PS) questionnaire was completed by parents at 42 months of age. HSCS-PS was grouped in four categories (neurosensory, learning, motor and quality of life). Logistic regression was used to identify perinatal risk factors associated with moderate/severe problems at 42 months of age. RESULT: Completed surveys were received for 261 term NICU survivors and 393 control children. Term infants represent 32% of all NICU admissions. Mean birth weight of NICU graduates was 3458 g (s.d.=600 g). Median length-of-stay in NICU was 5 days. At 42 months, the NICU group had significantly more problems on the HSCS-PS as compared to the full-term healthy infants in neurosensory, motor and learning/remembering. Moderate/severe health status problems were associated with congenital anomalies (odds ratio (OR), 3.2; confidence interval (CI): 1.3 to 7.8); smoking status (OR, 2.7, CI: 1.1 to 6.6) and SNAP score (OR, 1.04; CI: 1.0 to 1.1). CONCLUSION: Term babies admitted to NICUs may have significant health issues in childhood. Greater attention needs to be paid to long-term outcomes of term NICU graduates. Further study is warranted to address which NICU term survivors warrant secondary and/or tertiary-level neurodevelopmental follow-up. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NEURODEVELOPMENTAL OUTCOME OF PRETERM VERY LOW BIRTH WEIGHT INFANTS ADMITTED TO AN ITALIAN TERTIARY CENTER OVER AN 11-YEAR PERIOD Article Open access 11 August 2021 THE RELATIONSHIP OF NEURODEVELOPMENTAL IMPAIRMENT TO CONCURRENT EARLY CHILDHOOD OUTCOMES OF EXTREMELY PRETERM INFANTS Article 23 March 2021 HEALTH-RELATED QUALITY OF LIFE AT AGE 10 YEARS IN CHILDREN BORN EXTREMELY PRETERM Article 17 May 2024 REFERENCES * Aylward GP, Pfeiffer SI, Wright A, Verhulst SJ . Outcome studies of low birth weight infants published in the last decade: a metaanalysis. _J Pediatr_ 1989; 115(4): 515–520. Article  CAS  Google Scholar  * Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ . Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. _JAMA_ 2002; 288(6): 728–737. Article  Google Scholar  * Escobar GJ, Littenberg B, Petitti DB . Outcome among surviving very low birthweight infants: a meta-analysis. _Arch Dis Child_ 1991; 66(2): 204–211. Article  CAS  Google Scholar  * Grunau RE, Whitfield MF, Fay TB . Psychosocial and academic characteristics of extremely low birth weight (< or =800 g) adolescents who are free of major impairment compared with term-born control subjects. _Pediatrics_ 2004; 114(6): e725–e732. Article  Google Scholar  * Hack M . Young adult outcomes of very-low-birth-weight children. _Semin Fetal Neonatal Med_ 2006; 11(2): 127–137. Article  Google Scholar  * Hack M, Taylor HG, Drotar D, Schluchter M, Cartar L, Andreias L _et al_. Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. _JAMA_ 2005; 294(3): 318–325. Article  CAS  Google Scholar  * Saigal S . Perception of health status and quality of life of extremely low-birth weight survivors. The consumer, the provider, and the child. _Clin Perinatol_ 2000; 27(2): 403, 19, x. Article  CAS  Google Scholar  * Saigal S, den Ouden L, Wolke D, Hoult L, Paneth N, Streiner DL _et al_. School-age outcomes in children who were extremely low birth weight from four international population-based cohorts. _Pediatrics_ 2003; 112(4): 943–950. Article  Google Scholar  * Saigal S, Stoskopf BL, Streiner DL, Burrows E . Physical growth and current health status of infants who were of extremely low birth weight and controls at adolescence. _Pediatrics_ 2001; 108(2): 407–415. Article  CAS  Google Scholar  * Stjernqvist K, Svenningsen NW . Ten-year follow-up of children born before 29 gestational weeks: health, cognitive development, behaviour and school achievement. _Acta Paediatr_ 1999; 88(5): 557–562. Article  CAS  Google Scholar  * Vohr BR, Wright LL, Poole WK, McDonald SA . Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. _Pediatrics_ 2005; 116(3): 635–643. Article  Google Scholar  * Marlow N, Wolke D, Bracewell MA, Samara M, EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth. _N Engl J Med_ 2005; 352(1): 9–19. Article  CAS  Google Scholar  * Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O _et al_. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996–1997. _Pediatrics_ 2005; 116(6): 1391–1400. Article  Google Scholar  * Theunissen NC, Veen S, Fekkes M, Koopman HM, Zwinderman KA, Brugman E _et al_. Quality of life in preschool children born preterm. _Dev Med Child Neurol_ 2001; 43(7): 460–465. Article  CAS  Google Scholar  * Lindeke LL, Mills MM, Georgieff MK, Tanner ME, Wrbsky PM . Health, growth, and use of community services in NICU graduates at early school age. _J Pediatr Health Care_ 1998; 12(6 Part 1): 299–304. Article  CAS  Google Scholar  * Ludman L, Lansdown R, Spitz L . Factors associated with developmental progress of full term neonates who required intensive care. _Arch Dis Child_ 1989; 64(3): 333–337. Article  CAS  Google Scholar  * Philips III JB, Dickman HM, Resnick MB, Nelson Jr RM, Eitzman DV . Characteristics, mortality, and outcome of higher-birth weight infants who require intensive care. _Am J Obstet Gynecol_ 1984; 149(8): 875–879. Article  Google Scholar  * Gray JE, McCormick MC, Richardson DK, Ringer S . Normal birth weight intensive care unit survivors: outcome assessment. _Pediatrics_ 1996; 97(6 Part 1): 832–838. CAS  PubMed  Google Scholar  * Lian WB, Yeo CL, Ho LY . Two-year outcome of normal-birth-weight infants admitted to a Singapore neonatal intensive care unit. _Ann Acad Med Singapore_ 2002; 31(2): 199–205. CAS  PubMed  Google Scholar  * Lupton BA, Hill A, Roland EH, Whitfield MF, Flodmark O . Brain swelling in the asphyxiated term newborn: pathogenesis and outcome. _Pediatrics_ 1988; 82(2): 139–146. CAS  PubMed  Google Scholar  * Hageman JR, Dusik J, Keuler H, Bregman J, Gardner TH . Outcome of persistent pulmonary hypertension in relation to severity of presentation. _Am J Dis Child_ 1988; 142(3): 293–296. CAS  PubMed  Google Scholar  * Hintz SR, Benitz WE, Colby CE, Sheehan AM, Rycus P, Van Meurs KP _et al_. Utilization and outcomes of neonatal cardiac extracorporeal life support: 1996–2000. _Pediatr Crit Care Med_ 2005; 6(1): 33–38. Article  Google Scholar  * Ichiba H, Matsunami S, Itoh F, Ueda T, Ohsasa Y, Yamano T . Three-year follow up of term and near-term infants treated with inhaled nitric oxide. _Pediatr Int_ 2003; 45(3): 290–293. Article  CAS  Google Scholar  * Brown KL, Miles F, Sullivan ID, Hoskote A, Verhulst L, Ridout DA _et al_. Outcome in neonates with congenital heart disease referred for respiratory extracorporeal membrane oxygenation. _Acta Paediatr_ 2005; 94(9): 1280–1284. Article  Google Scholar  * Lipkin PH, Davidson D, Spivak L, Straube R, Rhines J, Chang CT . Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide. _J Pediatr_ 2002; 140(3): 306–310. Article  CAS  Google Scholar  * Rosenberg AA . Outcome in term infants treated with inhaled nitric oxide. _J Pediatr_ 2002; 140(3): 284–287. Article  Google Scholar  * Connolly MA, Johnson JA . Measuring quality of life in paediatric patients. _Pharmacoeconomics_ 1999; 16(6): 605–625. Article  CAS  Google Scholar  * Hack M . Consideration of the use of health status, functional outcome, and quality-of-life to monitor neonatal intensive care practice. _Pediatrics_ 1999; 103(1 Suppl E): 319–328. CAS  PubMed  Google Scholar  * Schmidt LJ, Garratt AM, Fitzpatrick R . Child/parent-assessed population health outcome measures: a structured review. _Child Care Health Dev_ 2002; 28(3): 227–237. Article  CAS  Google Scholar  * Saigal S, Rosenbaum P, Stoskopf B, Hoult L, Furlong W, Feeny D _et al_. Development, reliability and validity of a new measure of overall health for pre-school children. _Qual Life Res_ 2005; 14(1): 243–257. Article  CAS  Google Scholar  * Klassen AF, Landgraf JM, Lee SK, Barer M, Raina P, Chan HW _et al_. Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire. _Health Qual Life Outcomes_ 2003; 1(1): 81. Article  Google Scholar  * Varni JW, Seid M, Kurtin PS . PedsQL 4.0: reliability and validity of the pediatric quality of life inventory version 4.0 generic core scales in healthy and patient populations. _Med Care_ 2001; 39(8): 800–812. Article  CAS  Google Scholar  * Fekkes M, Theunissen NC, Brugman E, Veen S, Verrips EG, Koopman HM _et al_. Development and psychometric evaluation of the TAPQOL: a health-related quality of life instrument for 1–5-year-old children. _Qual Life Res_ 2000; 9(8): 961–972. Article  CAS  Google Scholar  * Saigal S, Stoskopf B, Streiner D, Boyle M, Pinelli J, Paneth N _et al_. Transition of extremely low-birth-weight infants from adolescence to young adulthood: comparison with normal birth-weight controls. _JAMA_ 2006; 295(6): 667–675. Article  CAS  Google Scholar  * Saigal S, Rosenbaum PL, Feeny D, Burrows E, Furlong W, Stoskopf BL _et al_. Parental perspectives of the health status and health-related quality of life of teen-aged children who were extremely low birth weight and term controls. _Pediatrics_ 2000; 105(3 Part 1): 569–574. Article  CAS  Google Scholar  * Theunissen NC, den-Ouden AL, Meulman JJ, Koopman HM, Verloove-Vanhorick SP, Wit JM . Health status development in a cohort of preterm children. _J Pediatr_ 2000; 137(4): 534–539. Article  CAS  Google Scholar  * Tideman E, Ley D, Bjerre I, Forslund M . Longitudinal follow-up of children born preterm: somatic and mental health, self-esteem and quality of life at age 19. _Early Hum Dev_ 2001; 61(2): 97–110. Article  CAS  Google Scholar  * Klassen AF, Lee SK, Raina P, Chan HW, Matthew D, Brabyn D . Health status and health-related quality of life in a population-based sample of neonatal intensive care unit graduates. _Pediatrics_ 2004; 113(3 Part 1): 594–600. Article  Google Scholar  * Lee SK, McMillan DD, Ohlsson A, Pendray M, Synnes A, Whyte R _et al_. Variations in practice and outcomes in the Canadian NICU network: 1996–1997. _Pediatrics_ 2000; 106(5): 1070–1079. Article  CAS  Google Scholar  * Richardson DK, McCormick MC, Gray JE, Goldmann DA . CRIB and SNAP. _Lancet_ 1994; 344(8915): 124–125. Article  CAS  Google Scholar  * Gray JE, Richardson DK, McCormick MC, Workman-Daniels K, Goldmann DA . Neonatal therapeutic intervention scoring system: a therapy-based severity-of-illness index. _Pediatrics_ 1992; 90(4): 561–567. CAS  PubMed  Google Scholar  * Chamberlayne R, Green B, Barer ML, Hertzman C, Lawrence WJ, Sheps SB . Creating a population-based linked health database: a new resource for health services research. _Can J Public Health_ 1998; 89(4): 270–273. CAS  PubMed  Google Scholar  * Becerra JE, Fry YW, Rowley DL . Morbidity estimates of conditions originating in the perinatal period: United States, 1986 through 1987. _Pediatrics_ 1991; 88(3): 553–559. CAS  PubMed  Google Scholar  * Rohininath T, O'Connell LA, Sheehan K, Corcoran D, Matthews TG, Clarke TA . Workload and short-term outcome of babies weighing 2,500 grams or more at birth admitted to the paediatric unit of the Rotunda Hospital. _J Matern Fetal Neonatal Med_ 2005; 17(2): 139–143. CAS  PubMed  Google Scholar  * Eisen M, Ware Jr JE, Donald CA, Brook RH . Measuring components of children's health status. _Med Care_ 1979; 17(9): 902–921. Article  CAS  Google Scholar  * Asch DA, Jedrziewski MK, Christakis NA . Response rates to mail surveys published in medical journals. _J Clin Epidemiol_ 1997; 50(10): 1129–1136. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The Hospital for Sick Children Foundation (Toronto) provided an operating grant for this study. Veronica Schiariti was the recipient of a trainee award from the Neonatal-Perinatal Interdisciplinary Capacity Enhancement (NICE) Team, which was funded by Canadian Institutes of Health Research (CIHR). From British Columbia Research Institute, Veronica Schiariti holds a Graduate Studentship. Anne Klassen holds a New Investigator Award from CIHR and a Scholar Award from Michael Smith Foundation for Research. We thank the Canadian Neonatal Network. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Sunny Hill Health Centre, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada V Schiariti, J S Houbé & A Synnes * Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada V Schiariti * Department of Pediatrics, McMaster University, Hamilton, ON, Canada A F Klassen * Department of Pediatrics, Centre for Health Innovation and Improvement, University of British Columbia, Vancouver, BC, Canada J S Houbé, A Synnes & S Lisonkova * Integrated Centre for Care Advancement through Research, University of Alberta, Edmonton, AB, Canada S K Lee Authors * V Schiariti View author publications You can also search for this author inPubMed Google Scholar * A F Klassen View author publications You can also search for this author inPubMed Google Scholar * J S Houbé View author publications You can also search for this author inPubMed Google Scholar * A Synnes View author publications You can also search for this author inPubMed Google Scholar * S Lisonkova View author publications You can also search for this author inPubMed Google Scholar * S K Lee View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to V Schiariti. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Schiariti, V., Klassen, A., Houbé, J. _et al._ Perinatal characteristics and parents' perspective of health status of NICU graduates born at term. _J Perinatol_ 28, 368–376 (2008). https://doi.org/10.1038/jp.2008.9 Download citation * Received: 29 August 2007 * Revised: 18 December 2007 * Accepted: 04 January 2008 * Published: 21 February 2008 * Issue Date: May 2008 * DOI: https://doi.org/10.1038/jp.2008.9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * neonatal intensive care unit * term birth * outcomes * health status * neonatology

ABSTRACT OBJECTIVE: Long-term outcomes of preterm infants have been extensively studied, but few studies have examined long-term outcomes of term infants who require neonatal intensive care


unit (NICU). Our objectives were to assess perinatal characteristics and health status of preschool age term babies using data from a population-based study of NICU graduates. STUDY DESIGN:


Retrospective cross-sectional survey. All babies were born in 1996 to 1997 in BC (Canada). The Health Status Classification System Preschool (HSCS-PS) questionnaire was completed by parents


at 42 months of age. HSCS-PS was grouped in four categories (neurosensory, learning, motor and quality of life). Logistic regression was used to identify perinatal risk factors associated


with moderate/severe problems at 42 months of age. RESULT: Completed surveys were received for 261 term NICU survivors and 393 control children. Term infants represent 32% of all NICU


admissions. Mean birth weight of NICU graduates was 3458 g (s.d.=600 g). Median length-of-stay in NICU was 5 days. At 42 months, the NICU group had significantly more problems on the HSCS-PS


as compared to the full-term healthy infants in neurosensory, motor and learning/remembering. Moderate/severe health status problems were associated with congenital anomalies (odds ratio


(OR), 3.2; confidence interval (CI): 1.3 to 7.8); smoking status (OR, 2.7, CI: 1.1 to 6.6) and SNAP score (OR, 1.04; CI: 1.0 to 1.1). CONCLUSION: Term babies admitted to NICUs may have


significant health issues in childhood. Greater attention needs to be paid to long-term outcomes of term NICU graduates. Further study is warranted to address which NICU term survivors


warrant secondary and/or tertiary-level neurodevelopmental follow-up. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution


ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article *


Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn


about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NEURODEVELOPMENTAL OUTCOME OF PRETERM VERY LOW BIRTH WEIGHT INFANTS


ADMITTED TO AN ITALIAN TERTIARY CENTER OVER AN 11-YEAR PERIOD Article Open access 11 August 2021 THE RELATIONSHIP OF NEURODEVELOPMENTAL IMPAIRMENT TO CONCURRENT EARLY CHILDHOOD OUTCOMES OF


EXTREMELY PRETERM INFANTS Article 23 March 2021 HEALTH-RELATED QUALITY OF LIFE AT AGE 10 YEARS IN CHILDREN BORN EXTREMELY PRETERM Article 17 May 2024 REFERENCES * Aylward GP, Pfeiffer SI,


Wright A, Verhulst SJ . Outcome studies of low birth weight infants published in the last decade: a metaanalysis. _J Pediatr_ 1989; 115(4): 515–520. Article  CAS  Google Scholar  * Bhutta


AT, Cleves MA, Casey PH, Cradock MM, Anand KJ . Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. _JAMA_ 2002; 288(6): 728–737. Article 


Google Scholar  * Escobar GJ, Littenberg B, Petitti DB . Outcome among surviving very low birthweight infants: a meta-analysis. _Arch Dis Child_ 1991; 66(2): 204–211. Article  CAS  Google


Scholar  * Grunau RE, Whitfield MF, Fay TB . Psychosocial and academic characteristics of extremely low birth weight (< or =800 g) adolescents who are free of major impairment


compared with term-born control subjects. _Pediatrics_ 2004; 114(6): e725–e732. Article  Google Scholar  * Hack M . Young adult outcomes of very-low-birth-weight children. _Semin Fetal


Neonatal Med_ 2006; 11(2): 127–137. Article  Google Scholar  * Hack M, Taylor HG, Drotar D, Schluchter M, Cartar L, Andreias L _et al_. Chronic conditions, functional limitations, and


special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. _JAMA_ 2005; 294(3): 318–325. Article  CAS  Google Scholar  * Saigal S . Perception of


health status and quality of life of extremely low-birth weight survivors. The consumer, the provider, and the child. _Clin Perinatol_ 2000; 27(2): 403, 19, x. Article  CAS  Google Scholar 


* Saigal S, den Ouden L, Wolke D, Hoult L, Paneth N, Streiner DL _et al_. School-age outcomes in children who were extremely low birth weight from four international population-based


cohorts. _Pediatrics_ 2003; 112(4): 943–950. Article  Google Scholar  * Saigal S, Stoskopf BL, Streiner DL, Burrows E . Physical growth and current health status of infants who were of


extremely low birth weight and controls at adolescence. _Pediatrics_ 2001; 108(2): 407–415. Article  CAS  Google Scholar  * Stjernqvist K, Svenningsen NW . Ten-year follow-up of children


born before 29 gestational weeks: health, cognitive development, behaviour and school achievement. _Acta Paediatr_ 1999; 88(5): 557–562. Article  CAS  Google Scholar  * Vohr BR, Wright LL,


Poole WK, McDonald SA . Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. _Pediatrics_ 2005; 116(3): 635–643. Article


  Google Scholar  * Marlow N, Wolke D, Bracewell MA, Samara M, EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth. _N Engl J Med_


2005; 352(1): 9–19. Article  CAS  Google Scholar  * Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O _et al_. Neurodevelopmental outcome at 5 years of age of a national


cohort of extremely low birth weight infants who were born in 1996–1997. _Pediatrics_ 2005; 116(6): 1391–1400. Article  Google Scholar  * Theunissen NC, Veen S, Fekkes M, Koopman HM,


Zwinderman KA, Brugman E _et al_. Quality of life in preschool children born preterm. _Dev Med Child Neurol_ 2001; 43(7): 460–465. Article  CAS  Google Scholar  * Lindeke LL, Mills MM,


Georgieff MK, Tanner ME, Wrbsky PM . Health, growth, and use of community services in NICU graduates at early school age. _J Pediatr Health Care_ 1998; 12(6 Part 1): 299–304. Article  CAS 


Google Scholar  * Ludman L, Lansdown R, Spitz L . Factors associated with developmental progress of full term neonates who required intensive care. _Arch Dis Child_ 1989; 64(3): 333–337.


Article  CAS  Google Scholar  * Philips III JB, Dickman HM, Resnick MB, Nelson Jr RM, Eitzman DV . Characteristics, mortality, and outcome of higher-birth weight infants who require


intensive care. _Am J Obstet Gynecol_ 1984; 149(8): 875–879. Article  Google Scholar  * Gray JE, McCormick MC, Richardson DK, Ringer S . Normal birth weight intensive care unit survivors:


outcome assessment. _Pediatrics_ 1996; 97(6 Part 1): 832–838. CAS  PubMed  Google Scholar  * Lian WB, Yeo CL, Ho LY . Two-year outcome of normal-birth-weight infants admitted to a Singapore


neonatal intensive care unit. _Ann Acad Med Singapore_ 2002; 31(2): 199–205. CAS  PubMed  Google Scholar  * Lupton BA, Hill A, Roland EH, Whitfield MF, Flodmark O . Brain swelling in the


asphyxiated term newborn: pathogenesis and outcome. _Pediatrics_ 1988; 82(2): 139–146. CAS  PubMed  Google Scholar  * Hageman JR, Dusik J, Keuler H, Bregman J, Gardner TH . Outcome of


persistent pulmonary hypertension in relation to severity of presentation. _Am J Dis Child_ 1988; 142(3): 293–296. CAS  PubMed  Google Scholar  * Hintz SR, Benitz WE, Colby CE, Sheehan AM,


Rycus P, Van Meurs KP _et al_. Utilization and outcomes of neonatal cardiac extracorporeal life support: 1996–2000. _Pediatr Crit Care Med_ 2005; 6(1): 33–38. Article  Google Scholar  *


Ichiba H, Matsunami S, Itoh F, Ueda T, Ohsasa Y, Yamano T . Three-year follow up of term and near-term infants treated with inhaled nitric oxide. _Pediatr Int_ 2003; 45(3): 290–293. Article


  CAS  Google Scholar  * Brown KL, Miles F, Sullivan ID, Hoskote A, Verhulst L, Ridout DA _et al_. Outcome in neonates with congenital heart disease referred for respiratory extracorporeal


membrane oxygenation. _Acta Paediatr_ 2005; 94(9): 1280–1284. Article  Google Scholar  * Lipkin PH, Davidson D, Spivak L, Straube R, Rhines J, Chang CT . Neurodevelopmental and medical


outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide. _J Pediatr_ 2002; 140(3): 306–310. Article  CAS  Google Scholar  * Rosenberg AA . Outcome in term


infants treated with inhaled nitric oxide. _J Pediatr_ 2002; 140(3): 284–287. Article  Google Scholar  * Connolly MA, Johnson JA . Measuring quality of life in paediatric patients.


_Pharmacoeconomics_ 1999; 16(6): 605–625. Article  CAS  Google Scholar  * Hack M . Consideration of the use of health status, functional outcome, and quality-of-life to monitor neonatal


intensive care practice. _Pediatrics_ 1999; 103(1 Suppl E): 319–328. CAS  PubMed  Google Scholar  * Schmidt LJ, Garratt AM, Fitzpatrick R . Child/parent-assessed population health outcome


measures: a structured review. _Child Care Health Dev_ 2002; 28(3): 227–237. Article  CAS  Google Scholar  * Saigal S, Rosenbaum P, Stoskopf B, Hoult L, Furlong W, Feeny D _et al_.


Development, reliability and validity of a new measure of overall health for pre-school children. _Qual Life Res_ 2005; 14(1): 243–257. Article  CAS  Google Scholar  * Klassen AF, Landgraf


JM, Lee SK, Barer M, Raina P, Chan HW _et al_. Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire. _Health Qual


Life Outcomes_ 2003; 1(1): 81. Article  Google Scholar  * Varni JW, Seid M, Kurtin PS . PedsQL 4.0: reliability and validity of the pediatric quality of life inventory version 4.0 generic


core scales in healthy and patient populations. _Med Care_ 2001; 39(8): 800–812. Article  CAS  Google Scholar  * Fekkes M, Theunissen NC, Brugman E, Veen S, Verrips EG, Koopman HM _et al_.


Development and psychometric evaluation of the TAPQOL: a health-related quality of life instrument for 1–5-year-old children. _Qual Life Res_ 2000; 9(8): 961–972. Article  CAS  Google


Scholar  * Saigal S, Stoskopf B, Streiner D, Boyle M, Pinelli J, Paneth N _et al_. Transition of extremely low-birth-weight infants from adolescence to young adulthood: comparison with


normal birth-weight controls. _JAMA_ 2006; 295(6): 667–675. Article  CAS  Google Scholar  * Saigal S, Rosenbaum PL, Feeny D, Burrows E, Furlong W, Stoskopf BL _et al_. Parental perspectives


of the health status and health-related quality of life of teen-aged children who were extremely low birth weight and term controls. _Pediatrics_ 2000; 105(3 Part 1): 569–574. Article  CAS 


Google Scholar  * Theunissen NC, den-Ouden AL, Meulman JJ, Koopman HM, Verloove-Vanhorick SP, Wit JM . Health status development in a cohort of preterm children. _J Pediatr_ 2000; 137(4):


534–539. Article  CAS  Google Scholar  * Tideman E, Ley D, Bjerre I, Forslund M . Longitudinal follow-up of children born preterm: somatic and mental health, self-esteem and quality of life


at age 19. _Early Hum Dev_ 2001; 61(2): 97–110. Article  CAS  Google Scholar  * Klassen AF, Lee SK, Raina P, Chan HW, Matthew D, Brabyn D . Health status and health-related quality of life


in a population-based sample of neonatal intensive care unit graduates. _Pediatrics_ 2004; 113(3 Part 1): 594–600. Article  Google Scholar  * Lee SK, McMillan DD, Ohlsson A, Pendray M,


Synnes A, Whyte R _et al_. Variations in practice and outcomes in the Canadian NICU network: 1996–1997. _Pediatrics_ 2000; 106(5): 1070–1079. Article  CAS  Google Scholar  * Richardson DK,


McCormick MC, Gray JE, Goldmann DA . CRIB and SNAP. _Lancet_ 1994; 344(8915): 124–125. Article  CAS  Google Scholar  * Gray JE, Richardson DK, McCormick MC, Workman-Daniels K, Goldmann DA .


Neonatal therapeutic intervention scoring system: a therapy-based severity-of-illness index. _Pediatrics_ 1992; 90(4): 561–567. CAS  PubMed  Google Scholar  * Chamberlayne R, Green B, Barer


ML, Hertzman C, Lawrence WJ, Sheps SB . Creating a population-based linked health database: a new resource for health services research. _Can J Public Health_ 1998; 89(4): 270–273. CAS 


PubMed  Google Scholar  * Becerra JE, Fry YW, Rowley DL . Morbidity estimates of conditions originating in the perinatal period: United States, 1986 through 1987. _Pediatrics_ 1991; 88(3):


553–559. CAS  PubMed  Google Scholar  * Rohininath T, O'Connell LA, Sheehan K, Corcoran D, Matthews TG, Clarke TA . Workload and short-term outcome of babies weighing 2,500 grams or


more at birth admitted to the paediatric unit of the Rotunda Hospital. _J Matern Fetal Neonatal Med_ 2005; 17(2): 139–143. CAS  PubMed  Google Scholar  * Eisen M, Ware Jr JE, Donald CA,


Brook RH . Measuring components of children's health status. _Med Care_ 1979; 17(9): 902–921. Article  CAS  Google Scholar  * Asch DA, Jedrziewski MK, Christakis NA . Response rates to


mail surveys published in medical journals. _J Clin Epidemiol_ 1997; 50(10): 1129–1136. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The Hospital for Sick Children


Foundation (Toronto) provided an operating grant for this study. Veronica Schiariti was the recipient of a trainee award from the Neonatal-Perinatal Interdisciplinary Capacity Enhancement


(NICE) Team, which was funded by Canadian Institutes of Health Research (CIHR). From British Columbia Research Institute, Veronica Schiariti holds a Graduate Studentship. Anne Klassen holds


a New Investigator Award from CIHR and a Scholar Award from Michael Smith Foundation for Research. We thank the Canadian Neonatal Network. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *


Department of Pediatrics, Sunny Hill Health Centre, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada V Schiariti, J S Houbé & A Synnes *


Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada V Schiariti * Department of Pediatrics, McMaster University, Hamilton, ON, Canada A F


Klassen * Department of Pediatrics, Centre for Health Innovation and Improvement, University of British Columbia, Vancouver, BC, Canada J S Houbé, A Synnes & S Lisonkova * Integrated


Centre for Care Advancement through Research, University of Alberta, Edmonton, AB, Canada S K Lee Authors * V Schiariti View author publications You can also search for this author inPubMed 


Google Scholar * A F Klassen View author publications You can also search for this author inPubMed Google Scholar * J S Houbé View author publications You can also search for this author


inPubMed Google Scholar * A Synnes View author publications You can also search for this author inPubMed Google Scholar * S Lisonkova View author publications You can also search for this


author inPubMed Google Scholar * S K Lee View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to V Schiariti. RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Schiariti, V., Klassen, A., Houbé, J. _et al._ Perinatal characteristics and parents' perspective of health


status of NICU graduates born at term. _J Perinatol_ 28, 368–376 (2008). https://doi.org/10.1038/jp.2008.9 Download citation * Received: 29 August 2007 * Revised: 18 December 2007 *


Accepted: 04 January 2008 * Published: 21 February 2008 * Issue Date: May 2008 * DOI: https://doi.org/10.1038/jp.2008.9 SHARE THIS ARTICLE Anyone you share the following link with will be


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initiative KEYWORDS * neonatal intensive care unit * term birth * outcomes * health status * neonatology