ABSTRACT OBJECTIVE: To replicate genetic associations with respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in genes related to surfactant deficiency, inflammation

and infection, and the renin–angiotensin system. STUDY DESIGN: We examined eight candidate genes for associations with RDS and BPD in 433 preterm birth (PTB—<37 weeks) infants (251 with

RDS and 134 with BPD). Both case–control and family-based analyses were performed in preterm (<37 weeks) and very preterm birth (VPTB—<32 weeks) infants. RESULT: We replicated a

previous finding that rs1923537, a marker downstream of surfactant protein D (_SFTPD_) is associated with RDS in VPTB infants in that the T allele was overtransmitted from parents to

_SFTPD_ and _ACE_ in the etiology of RDS and BPD, respectively. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS VERIFICATION OF IMMUNOLOGY-RELATED GENETIC ASSOCIATIONS IN BPD SUPPORTS _ABCA3_

AND FIVE OTHER GENES Article Open access 31 August 2021 BRONCHOPULMONARY DYSPLASIA AND WNT PATHWAY-ASSOCIATED SINGLE NUCLEOTIDE POLYMORPHISMS Article 01 December 2021 BRONCHOPULMONARY

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weight infants. _BMC Pediatr_ 2004; 4: 26. Article  Google Scholar  Download references ACKNOWLEDGEMENTS We would like to express our thanks to all the participating families in our study.

We would also like to express our gratitude to the coordinating medical and research staff at the University of Iowa Children's Hospital in Iowa City, IA, USA; including a special

thanks to research coordinators Susan Berends and Laura Knosp. Additionally, we would like to thank the research technician involved in genotyping and sample management including Tamara

Busch and students Rim Halaby and Jad al Danaf. This work was supported by the March of Dimes (Grants 1-FY05-126 and 6-FY08-260) and the NIH (Grants R01 HD-52953 and R01 HD-57192). Dr.

Ryckman's postdoctoral fellowship was supported by a NIH/NRSA T-32 training Grant (5T32 HL 007638-24). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Carver

College of Medicine, University of Iowa, Iowa City, IA, USA K K Ryckman, J M Dagle, K Kelsey, A M Momany & J C Murray * Department of Molecular Biology and Genetics, Cornell University,

Ithaca, NY, USA K Kelsey Authors * K K Ryckman View author publications You can also search for this author inPubMed Google Scholar * J M Dagle View author publications You can also search

for this author inPubMed Google Scholar * K Kelsey View author publications You can also search for this author inPubMed Google Scholar * A M Momany View author publications You can also

search for this author inPubMed Google Scholar * J C Murray View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to J C

Murray. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Journal of

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Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ryckman, K., Dagle, J., Kelsey, K. _et al._ Genetic associations of surfactant protein D and angiotensin-converting enzyme with

lung disease in preterm neonates. _J Perinatol_ 32, 349–355 (2012). https://doi.org/10.1038/jp.2011.104 Download citation * Received: 19 April 2011 * Revised: 28 June 2011 * Accepted: 11

July 2011 * Published: 29 September 2011 * Issue Date: May 2012 * DOI: https://doi.org/10.1038/jp.2011.104 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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KEYWORDS * bronchopulmonary dysplasia * respiratory distress syndrome * single-nucleotide polymorphism