ABSTRACT OBJECTIVE: To estimate the risk of death or tracheostomy placement (D/T) in infants with severe bronchopulmonary dysplasia (sBPD) born <32 weeks' gestation referred to

regional neonatal intensive care units. STUDY DESIGN: We conducted a retrospective cohort study in infants born <32 weeks’ gestation with sBPD in 2010–2011, using the Children's

Hospital Neonatal Database. sBPD was defined as the need for FiO2 ⩾0.3, nasal cannula support >2 l min−1 or positive pressure at 36 weeks' post menstrual age. The primary outcome was

D/T before discharge. Predictors associated with D/T in bivariable analyses (_P_<0.2) were used to develop a multivariable logistic regression equation using 80% of the cohort. This

mechanical ventilation at the time of referral, clinically diagnosed pulmonary hypertension, systemic corticosteroids after referral and occurrence of a bloodstream infection after referral

were each associated with D/T. The model performed well with validation (area under curve 0.86, goodness-of-fit _χ_2, _P_=0.66). CONCLUSION: Seven clinical variables predicted D/T in this

large, contemporary cohort with sBPD. These results can be used to inform clinicians who counsel families of affected infants and to assist in the design of future prospective trials. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS NEW BPD-PREVALENCE AND RISK FACTORS FOR BRONCHOPULMONARY DYSPLASIA/MORTALITY IN EXTREMELY LOW GESTATIONAL AGE INFANTS ≤28 WEEKS Article 24 May 2021

INVASIVE MECHANICAL VENTILATION AT 36 WEEKS POST-MENSTRUAL AGE, ADVERSE OUTCOMES WITH A COMPARISON OF RECENT DEFINITIONS OF BRONCHOPULMONARY DYSPLASIA Article Open access 25 May 2021 SEVERE

BRONCHOPULMONARY DYSPLASIA: OUTCOMES BEFORE AND AFTER THE IMPLEMENTATION OF AN INPATIENT MULTIDISCIPLINARY TEAM Article 23 October 2020 REFERENCES * Jobe AH . The new bronchopulmonary

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44–50. Article  Google Scholar  Download references ACKNOWLEDGEMENTS JMA, DJD, FDD, JRE (Chair), KM, MAP, EKP, KMR and BLS are members of the Children’s Hospital Neonatal Consortium, Inc.

The CHNC (http://www.thechnc.org) has partnered with Children’s Hospital Association, Inc. (Overland Park, KS, USA) to design, launch and maintain the CHND. We are indebted to the following

institutions that serve the infants and their families, and these institutions also have invested in and continue to participate in the Children’s Hospital’s Neonatal Database (CHND). For

more information please contact Kate Conrad ([email protected]). The site sponsors for the CHND are also included: 1 Children's Healthcare of Atlanta, Atlanta, GA (Francine

Dykes, Anthony Piazza) 2 Children’s Healthcare of Atlanta at Scottish Rite (Gregory Sysyn) 3 Children's Hospital of Alabama, Birmingham, AL (Carl Coghill) 4 Le Bonheur Children's

Hospital, Memphis, TN (Ramasubbareddy Dhanireddy) 5 Children's Hospital Boston, Boston, MA (Anne Hansen) 6 Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL (Karna

Murthy) 7 Nationwide Children's Hospital, Columbus, OH (Kristina Reber) 8 Children's Medical Center, Dallas, TX (Rashmin Savani, Luc Brion) 9 Children's Hospital Colorado,

Aurora, CO (Theresa Grover) 10 Children’s Hospital of Michigan, Detroit, MI (Girija Natarajan) 11 Cook Children's Health Care System, Fort Worth, TX (Jonathan Nedrelow, Annie Chi) 12

Texas Children's Hospital, Houston, TX (Yvette Johnson) 13 Children's Mercy Hospitals & Clinics, Kansas City, MO (Eugenia Pallotto) 14 Arkansas Children's Hospital, Little

Rock, AR (Becky Rodgers) 15 Children’s Hospital Los Angeles, Los Angeles, CA (Lisa Kelly*, Steven Chin) 16 Children's Hospital & Research Center Oakland, Oakland, CA (David Durand,

Jeanette Asselin) 17 The Children's Hospital of Philadelphia, Philadelphia, PA (Jacquelyn Evans, Michael Padula) 18 Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA

(Beverly Brozanski) 19 St Louis Children's Hospital, St Louis, MO (Joan Rosenbaum, Tasmin Najaf, Rakesh Rao, Amit Mathur) 20 All Children's Hospital, St. Petersburg, FL (Victor

McKay) 21 Rady Children's Hospital, San Diego, CA (Mark Speziale) 22 Children's National Medical Center, Washington, DC (Billie Short) 23 AI DuPont Hospital for Children,

Wilmington, DE (Kevin Sullivan) 24 Primary Children’s Medical Center, Salt Lake City, UT (Donald Null) 25 Children’s Hospital of Wisconsin, Milwaukee, WI (Michael Uhing) 26 Children’s

Hospital of Omaha (Lynne Willett, John Grebe) 27 Florida Hospital for Children (Rajan Wadhawan) *deceased AUTHOR INFORMATION Author notes * K Murthy, J M Asselin, D J Durand, B L Short, E K

Pallotto, M A Padula, F D Dykes, K M Reber and J R Evans: Form the Children’s Hospitals Neonatal Consortium (CHNC). AUTHORS AND AFFILIATIONS * Department of Pediatrics, Feinberg School of

Medicine, Northwestern University and the Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA K Murthy * Department of Pediatrics, University of Texas Southwestern

Medical Center and the Children’s Medical Center of Dallas, Dallas, TX, USA R C Savani * Department of Pediatrics, Medical College of Wisconsin and the Children’s Hospital of Wisconsin,

Milwaukee, WI, USA, J M Lagatta * Department of Analytics, Children’s Hospital Association, Overland Park, KS, USA, I Zaniletti * Department of Pediatrics, University of Central Florida and

the Florida Hospital for Children, Orlando, FL, USA R Wadhawan * Department of Pediatrics, University of Missouri-Kansas City School of Medicine and the Children’s Mercy Hospitals &

Clinics, Kansas, MO, USA W Truog & E K Pallotto * University of Colorado School of Medicine and the Colorado Children’s Hospital, Aurora, CO, USA, T R Grover * Department of Pediatrics,

Perelman School of Medicine at the University of Pennsylvania and the Children’s Hospital of Philadelphia, Philadelphia, PA, USA H Zhang, M A Padula & J R Evans * Department of

Pediatrics, Children’s Hospital Oakland & Research Center, Oakland, CA, USA J M Asselin & D J Durand * Department of Pediatrics, George Washington University School of Medicine and

Children’s National Medical Center, Washington, DC, USA, B L Short * Department of Pediatrics, Emory University School of Medicine and the Children’s Healthcare of Atlanta at Egleston,

Atlanta, GA, USA F D Dykes * Department of Pediatrics and Center for Perinatal Research, The Ohio State University College of Medicine and the Nationwide Children’s Hospital, Columbus, OH,

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View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to K Murthy. ETHICS DECLARATIONS COMPETING INTERESTS A portion of

JMA’s salary was provided by Children’s Hospital Association, Inc., for the development and maintenance of the database that was analyzed for this study. Remaining authors have no conflicts

of interest relevant to this article to disclose. Also, the Friends of Prentice Foundation, USA (Chicago, IL) sponsored a portion of this work. Dr RCS receives salary support from the

William Buchanan Chair in Pediatrics within his affiliated institution. The sponsors had no input in the study design, the collection, analysis and interpretation of data, the writing of the

report and the decision to submit the paper for publication. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Journal of Perinatology website SUPPLEMENTARY

INFORMATION SUPPLEMENTARY TABLE 1 (DOC 180 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Murthy, K., Savani, R., Lagatta, J. _et al._ Predicting

death or tracheostomy placement in infants with severe bronchopulmonary dysplasia. _J Perinatol_ 34, 543–548 (2014). https://doi.org/10.1038/jp.2014.35 Download citation * Received: 21

October 2013 * Revised: 27 January 2014 * Accepted: 05 February 2014 * Published: 20 March 2014 * Issue Date: July 2014 * DOI: https://doi.org/10.1038/jp.2014.35 SHARE THIS ARTICLE Anyone

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Springer Nature SharedIt content-sharing initiative KEYWORDS * neonatal intensive care * pulmonary hypertension * bloodstream infection * corticosteroids * Children’s Hospitals Neonatal

Consortium (CHNC) * Children’s Hospitals Neonatal Database