ABSTRACT OBJECTIVE: To determine whether the administration of mother’s colostrum into the buccal pouch in the first days of life alters the oral microbiota compared with control infants.

STUDY DESIGN: In this pilot study, 12 very low birth weight (VLBW) infants were randomly assigned to receive either colostrum from their mothers directly into the buccal pouch every 2 h for

46 h or standard care. We analyzed the oral microbiota at initiation and 48 and 96 h later using next-generation sequencing. RESULT: The oral microbiota changed markedly over the 96 h period

in all babies. Patterns of colonization differed between groups with Planococcaceae, the dominant family at 48 and 96 h in the colostrum group, and Moraxellaceae and Staphylococcaceae, the

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Ther_ 2015; 37 (5): 968–975. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS DAM acknowledges the Peter J. Shields Endowed Chair in Dairy Food Science at UC Davis. AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Division of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA K Sohn & M A Underwood * Department of Food

Science and Technology, University of California Davis, Davis,, CA, USA K M Kalanetra & D A Mills Authors * K Sohn View author publications You can also search for this author inPubMed 

Google Scholar * K M Kalanetra View author publications You can also search for this author inPubMed Google Scholar * D A Mills View author publications You can also search for this author

inPubMed Google Scholar * M A Underwood View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M A Underwood. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sohn, K., Kalanetra, K.,

Mills, D. _et al._ Buccal administration of human colostrum: impact on the oral microbiota of premature infants. _J Perinatol_ 36, 106–111 (2016). https://doi.org/10.1038/jp.2015.157

Download citation * Received: 22 July 2015 * Revised: 12 September 2015 * Accepted: 21 September 2015 * Published: 10 December 2015 * Issue Date: February 2016 * DOI:

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