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We sought to develop a prediction model to identify women with gestational diabetes (GDM) who require insulin to achieve glycemic control.
Retrospective cohort of all singletons with GDM treated with glyburide from 2007 to 2013. Glyburide failure was defined as reaching glyburide 20 mg day−1 and receiving insulin. Glyburide
success was defined as any glyburide dose without insulin and >70% of visits with glycemic control. Multivariable logistic regression analysis was performed to create a prediction model.
Of the 360 women, 63 (17.5%) qualified as glyburide failure and 157 (43.6%) as glyburide success. The final prediction model for glyburide failure included prior GDM, GDM diagnosis ⩽26
weeks, 1-h glucose challenge test ⩾228 mg dl−1, 3-h glucose tolerance test 1-h value ⩾221 mg dl−1, ⩾7 postprandial blood sugars >120 mg dl−1 in the week glyburide started and ⩾1 blood sugar
>200 mg dl−1. The model accurately classified 81% of subjects.
Women with GDM who will require insulin can be identified at the initiation of pharmacological therapy.
Dr Harper is supported by K12HD001258–13, PI WW Andrews, which partially supports this work.
Department of Obstetrics and Gynecology, Center for Women’s Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA
Presented as a poster at The Pregnancy Meeting, Society for Maternal Fetal Medicine, 6 February 2015, San Diego, CA, USA.
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