ABSTRACT Mutations in nucleophosmin (_NPM_) exon 12 and the resulting delocalization of NPM into the cytoplasm are the most specific and frequent cellular events in acute myeloid leukemia

patients (AML) with normal karyotype. Cytoplasmatic NPM (NPMc+) is associated with responsiveness to chemotherapy and better prognosis. The activation of nuclear factor-κB (NF-κB) has been

demonstrated to occur in a subset of AML patients and is thought to induce resistance to many chemotherapeutical agents. In this study, we demonstrate the increased _in vitro_ sensitivity of

NPMc+ cells to chemotherapeutical agents and their reduced NF-κB activity. Furthermore, we provide evidence of the interaction between NPMc+ and NF-κB in the cytoplasm, resulting in the

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(Associazione Italiana per la Ricerca sul Cancro), MURST-COFIN, AIL (Associazione Italiana contro le Leucemie) and Regione Piemonte. AUTHOR INFORMATION Author notes * D Cilloni and F Messa:

These authors contributed equally to this work. * E Messa: EM is a fellow of Gigi Ghirotti Foundation. AUTHORS AND AFFILIATIONS * Division of Hematology and Internal Medicine, Department of

Clinical and Biological Sciences of the University of Turin, Turin, Italy D Cilloni, F Messa, V Rosso, F Arruga, I Defilippi, S Carturan, R Catalano, M Pautasso, C Panuzzo, P Nicoli, E

Messa, A Morotti, E Bracco & G Saglio * Department of Hematology and Oncological Sciences, Division of Hematology, Seragnoli Institute, University of Bologna, Bologna, Italy I Iacobucci 

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ARTICLE CITE THIS ARTICLE Cilloni, D., Messa, F., Rosso, V. _et al._ Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between _NPM_ leukemic mutant and NF-κB

in AML carrying _NPM1_ mutations. _Leukemia_ 22, 1234–1240 (2008). https://doi.org/10.1038/leu.2008.68 Download citation * Received: 17 August 2007 * Revised: 16 February 2008 * Accepted: 19

February 2008 * Published: 10 April 2008 * Issue Date: June 2008 * DOI: https://doi.org/10.1038/leu.2008.68 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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KEYWORDS * NPM1 * NF-κB * acute leukemia * chemosensitivity