ABSTRACT Suicidal behavior is heritable, with the transmission of risk being related to the transmission of vulnerability traits. Previous studies suggest that risky decision-making may be

an endophenotype of suicide. Here, we aimed at investigating brain processing of decision-making in relatives of suicide completers in order to shed light on heritable mechanisms of suicidal

vulnerability. Seventeen healthy first-degree biological relatives of suicide completers with no personal history of suicidal behavior, 16 relatives of depressed patients without any

personal or family history of suicidal behavior, and 19 healthy controls were recruited. Functional 3 T magnetic resonance imaging scans were acquired while participants underwent the Iowa

basis of familial depression. Moreover, controls in comparison to relatives showed increased contrast in several regions including the post-central gyrus, posterior cingulate and parietal

cortices, and cerebellum (culmen) in familial suicide; and inferior parietal, temporal, occipital, anteromedial and dorsolateral prefrontal cortices, and cerebellum (vermis) in familial

depression. These findings most likely represent a complex combination of vulnerability and protective mechanisms in relatives. They also support a significant role for deficient risk

processing, and ventral and dorsal prefrontal cortex functioning in the suicidal diathesis. Access through your institution Buy or subscribe This is a preview of subscription content, access

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SUICIDE FROM FAMILIAL RISK FACTORS FOR DEPRESSION Article 31 May 2021 VENTRAL PREFRONTAL SEROTONIN 1A RECEPTOR BINDING: A NEURAL MARKER OF VULNERABILITY FOR MOOD DISORDER AND SUICIDAL

BEHAVIOR? Article 27 June 2022 PREFRONTAL ACTIVATION IN SUICIDE ATTEMPTERS DURING DECISION MAKING WITH EMOTIONAL FEEDBACK Article Open access 18 September 2020 REFERENCES * Jollant F,

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2014; 45C: 9–18. Article  Google Scholar  Download references ACKNOWLEDGEMENTS This study was funded thanks to a grant from the American Foundation for Suicide Prevention to Dr F. Jollant.

M. Y. Ding held a Fond de Recherche du Québec—Santé (FRQS) Ph.D. Grant # 24117 and Dr. F Jollant a FRQS 'chercheur-boursier clinicien' salary grant during this study. The sponsors

had no role in the design, data analyses or manuscript writing. We thank Mrs Annukka Jäkälä for data collection. Preliminary results from this study have been presented at the Society of

Biological Psychiatry’s 69th Annual Meeting in New York on 9 May 2014. AUTHOR INFORMATION Author notes * Y Ding and F Pereira: These authors contributed equally to this work. AUTHORS AND

AFFILIATIONS * Department of Psychiatry & Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada Y Ding, A Hoehne, M-M Beaulieu, M Lepage, G Turecki & F

Jollant * Department of Radiology, CHU Nîmes, Nîmes, France F Pereira * Department of Psychiatry, CHU Nîmes, Nîmes, France F Jollant Authors * Y Ding View author publications You can also

search for this author inPubMed Google Scholar * F Pereira View author publications You can also search for this author inPubMed Google Scholar * A Hoehne View author publications You can

also search for this author inPubMed Google Scholar * M-M Beaulieu View author publications You can also search for this author inPubMed Google Scholar * M Lepage View author publications

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publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to F Jollant. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

conflict of interest. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Molecular Psychiatry website SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION (DOCX 387

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brain processing of decision-making in healthy first-degree biological relatives of suicide completers. _Mol Psychiatry_ 22, 1149–1154 (2017). https://doi.org/10.1038/mp.2016.221 Download

citation * Received: 12 November 2015 * Revised: 12 October 2016 * Accepted: 17 October 2016 * Published: 13 December 2016 * Issue Date: August 2017 * DOI:

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