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Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into
three distinct phases according to their differential requirements for talin function. Access through your institution Buy or subscribe This is a preview of subscription content, access via
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CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Margaret Frame is at the Edinburgh Cancer Research Centre, Institute of Genetics and Molecular
Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR. [email protected], Margaret Frame * Jim Norman is at the Beatson Institute for Cancer
Research, Glasgow Garscube Estate, Switchback Road, Glasgow G61 1BD. [email protected], Jim Norman Authors * Margaret Frame View author publications You can also search for this
author inPubMed Google Scholar * Jim Norman View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Frame, M., Norman, J. A tal(in) of cell spreading. _Nat Cell Biol_ 10, 1017–1019 (2008). https://doi.org/10.1038/ncb0908-1017 Download citation * Issue Date:
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