Play all audios:
Providing chemical matter to modulate newly identified biological targets—as well as pre-existing but chemically intractable ones—remains a challenge in the discovery of therapeutics. Here,
we discuss opportunities for synthetic chemists to make a direct impact in addressing targets that are considered 'undruggable'. Access through your institution Buy or subscribe
This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access
$259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are
calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Austad, B.C. et al. _Synlett_
24, 333–337 (2013). Article CAS Google Scholar * Shi, J. et al. _J. Am. Chem. Soc._ 133, 8014–8027 (2011). Article CAS Google Scholar * Mousseau, G. et al. _Cell Host Microbe_ 12,
97–108 (2012). Article CAS Google Scholar * Hegde, N.S., Sanders, D.A., Rodriguez, R. & Balasubramanian, S. _Nat. Chem._ 3, 725–731 (2011). Article CAS Google Scholar * O'
Connor, C.J., Beckmann, H.S.G. & Spring, D.R. _Chem. Soc. Rev._ 41, 4444–4456 (2012). Article CAS Google Scholar * Marcaurelle, L.A., Johannes, C., Yohannes, D., Tillotson, B.P. &
Mann, D. _Bioorg. Med. Chem. Lett._ 19, 2500–2503 (2009). Article CAS Google Scholar * Heidebrecht, R.W. Jr. et al. _ACS Med. Chem. Lett._ 3, 112–117 (2012). Article CAS Google Scholar
* Walji, A.M. & MacMillan, D.W.C. _Synlett._ 2007, 1477–1489 (2007). Article Google Scholar * Zhou, H. et al. _J. Med. Chem._ doi:10.1021/jm3015298 (17 January 2013). * Marcaurelle,
L.A. et al. _J. Am. Chem. Soc._ 132, 16962–16976 (2010). Article Google Scholar * Hili, R., Rai, V. & Yudin, A.K. _J. Am. Chem. Soc._ 132, 2889–2891 (2010). Article CAS Google
Scholar * Bachovchin, D.A. et al. _Proc. Natl. Acad. Sci. USA_ 108, 6811–6816 (2011). Article CAS Google Scholar * Schulz, M.N. & Hubbard, R.E. _Curr. Opin. Pharmacol._ 9, 615–621
(2009). Article CAS Google Scholar * Sun, Q. et al. _Angew. Chem. Int. Ed. Engl._ 51, 6140–6143 (2012). Article CAS Google Scholar * Maurer, T. et al. _Proc. Natl. Acad. Sci. USA_ 109,
5299–5304 (2012). Article CAS Google Scholar * Bamborough, P. et al. _J. Med. Chem._ 55, 587–596 (2012). Article CAS Google Scholar * Dai, H.-X., Stepan, A.F., Plummer, M.S., Zhang,
Y.-H. & Yu, J.-Q. _J. Am. Chem. Soc._ 133, 7222–7228 (2011). Article CAS Google Scholar * Over, B. et al. _Nat. Chem._ 5, 21–28 (2013). Article CAS Google Scholar * Hung, A.W. et
al. _Proc. Natl. Acad. Sci. USA_ 108, 6799–6804 (2011). Article CAS Google Scholar * Hajduk, P.J., Galloway, W.R. & Spring, D.R. _Nature_ 470, 42–43 (2011). Article CAS Google
Scholar * Verdine, G.L. & Hilinski, G.J. _Drug Discov. Today. Technol._ 9, e41–e47 (2012). Article CAS Google Scholar * Bernal, F. et al. _Cancer Cell_ 18, 411–422 (2010). Article
CAS Google Scholar * Grossmann, T.N. et al. _Proc. Natl. Acad. Sci. USA_ 109, 17942–17947 (2012). Article CAS Google Scholar * Madden, M.M. et al. _Bioorg. Med. Chem. Lett._ 21,
1472–1475 (2011). Article CAS Google Scholar * Yan, C. & Higgins, P.J. _Biochim. Biophys. Acta_ 1835, 76–85 (2013). CAS PubMed Google Scholar * Clemons, P.A. et al. _Proc. Natl.
Acad. Sci. USA_ 108, 6817–6822 (2011). Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Sarathy Kesavan and Lisa A. Marcaurelle are at H3
Biomedicine Inc., Cambridge, Massachusetts, USA., Sarathy Kesavan & Lisa A Marcaurelle Authors * Sarathy Kesavan View author publications You can also search for this author inPubMed
Google Scholar * Lisa A Marcaurelle View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Lisa A Marcaurelle. ETHICS
DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kesavan, S.,
Marcaurelle, L. Translational synthetic chemistry. _Nat Chem Biol_ 9, 210–213 (2013). https://doi.org/10.1038/nchembio.1207 Download citation * Published: 18 March 2013 * Issue Date: April
2013 * DOI: https://doi.org/10.1038/nchembio.1207 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative