Protein kinases have emerged as one of the most successful families of drug targets. To date, most selective kinase inhibitors have been discovered serendipitously either through broad

selectivity screening or through the discovery of unique binding modes. Here we discuss design strategies that could lead to a broader coverage of the kinome with selective inhibitors and to

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Susanne Müller and Apirat Chaikuad are at the Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK., Susanne Müller & Apirat

Chaikuad * Nathanael S. Gray is at the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Nathanael S Gray * Stefan Knapp is at the

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK and the Institute for Pharmaceutical Chemistry and Buchmann Institute for Molecular

Life Sciences, Johann Wolfgang Goethe-University, Frankurt am Main, Germany., Stefan Knapp Authors * Susanne Müller View author publications You can also search for this author inPubMed 

Google Scholar * Apirat Chaikuad View author publications You can also search for this author inPubMed Google Scholar * Nathanael S Gray View author publications You can also search for this

author inPubMed Google Scholar * Stefan Knapp View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Nathanael S Gray

or Stefan Knapp. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Müller, S., Chaikuad, A., Gray, N. _et al._ The ins and outs of selective kinase inhibitor development. _Nat Chem Biol_ 11, 818–821 (2015). https://doi.org/10.1038/nchembio.1938

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