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Access through your institution Buy or subscribe Gordon JN _et al_. (2005) Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. _Gut_ 54: 540–545 Profound
metabolic disturbances resulting in severe muscle and fat wasting (cachexia) are significant in patients with advanced cancer. Several proinflammatory cytokines have been implicated in
development of cachexia and anorexia; modulation of their effects might improve outcome in these patients. As thalidomide has been shown to downregulate the production of proinflammatory
cytokines and improve cachexia associated with other conditions, its effect was investigated in this open-label, randomized, placebo-controlled trial in patients with advanced inoperable
pancreatic cancer. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and
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This article was published with the same DOI as a previous publication. A new DOI has been assigned and registered at Crossref, and has been corrected in the article. _ RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thalidomide for attenuation of weight loss during advanced pancreatic cancer. _Nat Rev Gastroenterol Hepatol_ 2, 206
(2005). https://doi.org/10.1038/ncponc0159x Download citation * Issue Date: 01 May 2005 * DOI: https://doi.org/10.1038/ncponc0159x SHARE THIS ARTICLE Anyone you share the following link
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