ABSTRACT To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation

analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal

transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of _Cd36_ encoding fatty acid translocase as a genetically determined risk

factor for spontaneous hypertension. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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ACKNOWLEDGEMENTS The authors acknowledge funding support to T.W.K. from the US National Institutes of Health, to L.K. and O.V. from the Ministry of Health of the Czech Republic, to M.P.,

N.H. and T.J.A. from the European Commission within the Sixth Framework Programme through the Integrated Project EURATools, to M.P. from the Grant Agency of the Academy of Sciences of the

Czech Republic, to M.P. and V.K. from Ministry of Education of the Czech Republic, and to N.H. from the German Ministry for Science and Education (National Genome Research Network). M.P. is

an International Research Scholar of the Howard Hughes Medical Institute. E.P. is a Research Councils UK Fellow. AUTHOR INFORMATION Author notes * Paul C Churchill: Deceased. AUTHORS AND

AFFILIATIONS * Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, 14220, Czech Republic Michal Pravenec, Vaclav Zidek, Vladimir

Landa, Vladimir Kren & Petr Mlejnek * Institute of Biology and Medical Genetics, First Medical Faculty and General Teaching Hospital, Charles University, Prague, 12800, Czech Republic

Michal Pravenec & Vladimir Kren * Department of Physiology, Wayne State University School of Medicine, Detroit, 48201, Michigan, USA Paul C Churchill, Monique C Churchill & Joseph

Dunbar * Institute for Clinical and Experimental Medicine, Prague, 14021, Czech Republic Ondrej Viklicky, Ludmila Kazdova & Martina Maxova * MRC Clinical Sciences Centre, Faculty of

Medicine, Imperial College, London, W12 ONN, UK Timothy J Aitman, Enrico Petretto & Caroline A Wallace * Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine,

Imperial College, London, W12 ONN, UK Enrico Petretto * Max Delbruck Center for Molecular Medicine, Berlin-Buch, 13125, Germany Norbert Hubner & Heike Zimdahl * Department of Internal

Medicine, Loyola University and Hines VA Hospital, Maywood, 60153, Illinois, USA Anil Bidani & Karen Griffin * Department of Medicine, University of Michigan Medical School, Ann Arbor,

48109, Michigan, USA Nathan Qi * Department of Laboratory Medicine, University of California, San Francisco, 94107, California, USA Jiaming Wang & Theodore W Kurtz Authors * Michal

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M., Churchill, P., Churchill, M. _et al._ Identification of renal _Cd36_ as a determinant of blood pressure and risk for hypertension. _Nat Genet_ 40, 952–954 (2008).

https://doi.org/10.1038/ng.164 Download citation * Received: 14 February 2008 * Accepted: 05 May 2008 * Published: 29 June 2008 * Issue Date: August 2008 * DOI:

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