ABSTRACT Psoriatic arthritis (PsA) is an inflammatory joint disease that is distinct from other chronic arthritides and which is frequently accompanied by psoriasis vulgaris (PsV) and

seronegativity for rheumatoid factor. We conducted a genome-wide association study in 609 German individuals with PsA (cases) and 990 controls with replication in 6 European cohorts

including a total of 5,488 individuals. We replicated PsA associations at _HLA-C_ and _IL12B_ and identified a new association at _TRAF3IP2_ (rs13190932, _P_ = 8.56 × 10−17). _TRAF3IP2_ was

also associated with PsV in a German cohort including 2,040 individuals (rs13190932, _P_ = 1.95 × 10−3). Sequencing of the exons of _TRAF3IP2_ identified a coding variant (p.Asp10Asn,

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OF PSORIASIS IN THE POST-GENOME-WIDE ASSOCIATION ERA Article 16 September 2023 GWAS META-ANALYSIS OF PSORIASIS IDENTIFIES NEW SUSCEPTIBILITY ALLELES IMPACTING DISEASE MECHANISMS AND

THERAPEUTIC TARGETS Article Open access 28 February 2025 LOW-FREQUENCY AND RARE GENETIC VARIANTS ASSOCIATED WITH RHEUMATOID ARTHRITIS RISK Article 27 March 2024 ACCESSION CODES ACCESSIONS

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_J. Med. Genet._ 46, 736–744 (2009). Google Scholar  Download references ACKNOWLEDGEMENTS We are grateful to all subjects and control probands for participation in this study. We thank P.

Rothe, M. Kirsch, P. Badorf, P. Gilbert and K. Krause for excellent technical assistance. We thank D. Fried for helping with the cloning of constructs. The work was supported in part by a

grant from the Interdisciplinary Centre for Clinical Research (IZKF B32/A8) of the University of Erlangen-Nuremberg and a grant from the ELAN fund (Erlanger Leistungsbezogene

Anschubfinanzierung und Nachwuchsförderung) of the University of Erlangen-Nuremberg. The KORA (Cooperative Health Research in the Region of Augsburg) research platform was initiated and

financed by the Helmholtz Center Munich, German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of

Bavaria. Part of this work was financed by the German National Genome Research Network (NGFN-2 and NGFNPlus: 01GS0823). Our research was supported within the Munich Center of Health Sciences

(MC Health) as part of LMUinnovativ. We acknowledge the National Institute for Health Research, Manchester Biomedical Research Centre and Science Foundation Ireland for support. A.B.,

I.N.B. and J.B. are funded by Arthritis Research. H.B. and F.B. were supported by a research grant of Wyeth Pharma GmbH, Germany (Forschungsförderungspreis Rheumatologie 2008). E.G. and G.N.

are funded by the ADIPSO (Association for the Defense of Psoriasis Patients). The Irish control DNA was provided by the Irish Blood Transfusion Service and Trinity College Dublin population

DNA Biobank. This study makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is

available from http://www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113. U.H., E.G., E.K., M.A., P.H., I.N.B., F.B., O.F., G.-M.A., N.J.M.,

G.N., H.B., A.B. and A.R. are members of the Psoriatic Arthritis Genetics in Europe (PAGE) Consortium. AUTHOR INFORMATION Author notes * Jesús Lascorz Present address: Present address:

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., * Ulrike Hüffmeier and Steffen Uebe: These authors contributed equally to this work. *

Harald Burkhardt, Anne Barton and André Reis: These authors jointly supervised this work. AUTHORS AND AFFILIATIONS * Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen,

Germany Ulrike Hüffmeier, Steffen Uebe, Arif B Ekici, Maria Apel, Jesús Lascorz & André Reis * Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The

University of Manchester, Manchester, UK John Bowes, Pauline Ho, Ian N Bruce & Anne Barton * Department of Biopathology, Centre of Excellence for Genomic Risk Assessment in

Multifactorial and Complex Diseases, School of Medicine, University of Rome 'Tor Vergata' and Fondazione PTV 'Policlinico Tor Vergata', Rome, Italy Emiliano Giardina 

& Giuseppe Novelli * Royal National Hospital for Rheumatic Diseases, Bath, UK Eleanor Korendowych & Neil J McHugh * Department of Public Health and Clinical Medicine, Rheumatology,

University Hospital, Umeå, Sweden Kristina Juneblad & Gerd-Marie Alenius * Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland Ross

McManus & Anthony W Ryan * Division of Rheumatology, Department of Internal Medicine II, Johann Wolfgang Goethe University, Frankfurt am Main, Germany Frank Behrens, Beate Böhm & 

Harald Burkhardt * Department of Dermatology, University of Münster, Münster, Germany Heiko Traupe * Psoriasis Rehabilitation Hospital, Bad Bentheim, Germany Jörg Lohmann * Institute of

Epidemiology, Helmholtz Center Munich, Munich, Germany Christian Gieger & Heinz-Erich Wichmann * Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology,

Ludwig-Maximilians-Universität, Munich, Germany Heinz-Erich Wichmann * Klinikum Grosshadern, Munich, Germany Heinz-Erich Wichmann * Institute of Medical Biometry, Informatics and

Epidemiology, University of Bonn, Bonn, Germany Christine Herold, Michael Steffens & Thomas F Wienker * Karolinska Institute, Stockholm, Sweden Lars Klareskog * Department of

Rheumatology, St. Vincent's University Hospital, University College Dublin (UCD) School of Medicine and Medical Science and Conway Institute of Biomolecular and Biomedical Research,

University College Dublin, Dublin, Ireland Oliver FitzGerald * Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Neil J McHugh Authors * Ulrike Hüffmeier View author

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for this author inPubMed Google Scholar CONTRIBUTIONS H.B., A.B. and A.R. designed the study and worked out its concept. U.H., A.B.E., M.A. and J.B. planned and performed genotyping with

genome-wide arrays and/or assays for single SNPs, and U.H., S.U., A.B.E., J.B., M.A., C.H., M.S., T.F.W. and A.R. analyzed genetic data. B.B. and H.B. performed functional studies. U.H.,

J.B., E.G., E.K., K.J., R.M., P.H., I.N.B., A.W.R., F.B., J. Lascorz, H.T., J. Lohmann, C.G., H.-E.W., O.F., G.-M.A., N.J.M., G.N., H.B. and A.B. recruited subjects and control individuals

and collected the phenotypic data. U.H., S.U., H.B. and A.R. wrote a first draft of the manuscript. A.B. edited the manuscript in a major way. All authors reviewed and approved the

manuscript. CORRESPONDING AUTHOR Correspondence to André Reis. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION

SUPPLEMENTARY TEXT AND FIGURES Supplementary Figures 1–3, Supplementary Tables 1–4 and Supplementary Note. (PDF 819 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Hüffmeier, U., Uebe, S., Ekici, A. _et al._ Common variants at _TRAF3IP2_ are associated with susceptibility to psoriatic arthritis and psoriasis. _Nat Genet_ 42, 996–999

(2010). https://doi.org/10.1038/ng.688 Download citation * Received: 25 January 2010 * Accepted: 13 September 2010 * Published: 17 October 2010 * Issue Date: November 2010 * DOI:

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