ABSTRACT Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two–bottle choice paradigm) of C57BL/6J

mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption

(the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are

responsible for nearly 85% of the genetic variance observed between the two parental strains. Access through your institution Buy or subscribe This is a preview of subscription content,

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Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychiatry and Human Behavior, Thomas Jefferson University,

Philadelphia, Pennsylvania, 19107, USA Wade H. Berrettini, Thomas N. Ferraro & Robert C. Alexander * Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania,

19107, USA Arthur M. Buchberg * Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA Wolfgang H. Vogel Authors * Wade H. Berrettini View author

publications You can also search for this author inPubMed Google Scholar * Thomas N. Ferraro View author publications You can also search for this author inPubMed Google Scholar * Robert C.

Alexander View author publications You can also search for this author inPubMed Google Scholar * Arthur M. Buchberg View author publications You can also search for this author inPubMed 

Google Scholar * Wolfgang H. Vogel View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Berrettini, W., Ferraro, T., Alexander, R. _et al._ Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. _Nat Genet_ 7,

54–58 (1994). https://doi.org/10.1038/ng0594-54 Download citation * Received: 03 November 1993 * Accepted: 25 February 1994 * Issue Date: 01 May 1994 * DOI:

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