Play all audios:
ABSTRACT Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the
intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most
pronounced cases of functional population diversity in the human genome. Access through your institution Buy or subscribe This is a preview of subscription content, access via your
institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this
article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS THE _UGT2A1/UGT2A2_ LOCUS IS ASSOCIATED WITH COVID-19-RELATED LOSS
OF SMELL OR TASTE Article 17 January 2022 IMPACT OF LOW-FREQUENCY CODING VARIANTS ON HUMAN FACIAL SHAPE Article Open access 12 January 2021 GENETIC VARIANTS UNDERLYING DIFFERENCES IN FACIAL
MORPHOLOGY IN EAST ASIAN AND EUROPEAN POPULATIONS Article 07 April 2022 REFERENCES * Glusman, G., Yanai, I., Rubin, I. & Lancet, D. _Genome Res._ 11, 685–702 (2001). Article CAS
Google Scholar * Zhang, X. & Firestein, S. _Nat. Neurosci._ 5, 124–133 (2002). Article CAS Google Scholar * Young, J.M. et al. _Hum. Mol. Genet._ 11, 535–546 (2002). Article CAS
Google Scholar * Gilad, Y., Man, O., Paabo, S. & Lancet, D. _Proc. Natl. Acad. Sci. USA_ 100, 3324–3327 (2003). Article CAS Google Scholar * Ehlers, A. et al. _Genome Res._ 10,
1968–1978 (2000). Article CAS Google Scholar * Menashe, I., Man, O., Lancet, D. & Gilad, Y. _Hum. Mol. Genet._ 11, 1381–1390 (2002). Article CAS Google Scholar * Gilad, Y. &
Lancet, D. _Mol. Biol. Evol._ 20, 307–314 (2003). Article CAS Google Scholar * Amoore, J.E. _Ann. NY Acad. Sci._ 237, 137–143 (1974). Article CAS Google Scholar * Whissell-Buechy, D.
& Amoore, J.E. _Nature_ 242, 271–273 (1973). Article CAS Google Scholar * Schoneberg, T., Schulz, A. & Gudermann, T. _Rev. Physiol. Biochem. Pharmacol._ 144, 143–227 (2002). CAS
PubMed Google Scholar * Wysocki, C.J. & Beauchamp, G.K. _Proc. Natl. Acad. Sci. USA_ 81, 4899–4902 (1984). Article CAS Google Scholar * Yeager, M. & Hughes, A.L. _Immunol. Rev._
167, 45–58 (1999). Article CAS Google Scholar * Barron, K.S. & Robinson, M.A. _Hum. Immunol._ 40, 17–19 (1994). Article CAS Google Scholar * Harrison, P.M. et al. _Genome Res._
12, 272–280 (2002). Article CAS Google Scholar Download references ACKNOWLEDGEMENTS We thank M. Przeworski for helpful discussions. D.L. holds the Ralph and Lois Silver Chair in Human
Genomics. This work was supported by the Crown Human Genome Center at the Weizmann Institute of Science and by an Israel Ministry of Science grant to the National Laboratory for Genome
Infrastructure. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, 76100, Israel
Idan Menashe, Orna Man, Doron Lancet & Yoav Gilad Authors * Idan Menashe View author publications You can also search for this author inPubMed Google Scholar * Orna Man View author
publications You can also search for this author inPubMed Google Scholar * Doron Lancet View author publications You can also search for this author inPubMed Google Scholar * Yoav Gilad View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Doron Lancet. ETHICS DECLARATIONS COMPETING INTERESTS The authors
declare no competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY NOTE (PDF 90 KB) SUPPLEMENTARY TABLE 1 (PDF 108 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT
THIS ARTICLE CITE THIS ARTICLE Menashe, I., Man, O., Lancet, D. _et al._ Different noses for different people. _Nat Genet_ 34, 143–144 (2003). https://doi.org/10.1038/ng1160 Download
citation * Received: 15 January 2003 * Accepted: 28 March 2003 * Published: 05 May 2003 * Issue Date: 01 June 2003 * DOI: https://doi.org/10.1038/ng1160 SHARE THIS ARTICLE Anyone you share
the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer
Nature SharedIt content-sharing initiative