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Access through your institution Buy or subscribe The contributions of various dendritic cell (DC) subsets to the generation of effector versus memory CD8+ T cells remains unclear. In
_Immunity_, Lin _et al_. show that lung CD103+ or CD11b+ migratory DCs activate naive CD8+ T cells differently during infection with influenza virus. Through the use of mice deficient in
CD103+ DCs, the authors show this DC subset is required for the efficient generation of virus-specific CD8+ T cells with an effector or effector-memory phenotype in the lymph nodes and the
migration of those cells to the lungs. However, the generation of CD8+ T cells with a central memory phenotype is supported mostly by the CD11b+ DC subset. CD103+ DCs have tenfold higher
expression of CD24, which serves as a costimulatory ligand for the differentiation of effector CD8+ T cells at least in part through capture of the alarmin HMGB1 and engagement of the
receptor RAGE on CD8+ T cells. Thus, different intrinsic properties of DCs dictate the outcome of the effector or memory differentiation of CD8+ T cells. _Immunity_ 40, 400–413 (2014) This
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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Ioana Visan View author publications You
can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Visan, I. DC division of labor. _Nat Immunol_ 15,
414 (2014). https://doi.org/10.1038/ni.2880 Download citation * Published: 18 April 2014 * Issue Date: May 2014 * DOI: https://doi.org/10.1038/ni.2880 SHARE THIS ARTICLE Anyone you share
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