ABSTRACT Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the

adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent. Studies of

'translatomes' (genome-wide pools of translated mRNA) have facilitated mechanistic discoveries by identifying key regulatory components, including transcription factors, that are

under translational control. Here we review the current knowledge on mechanisms that regulate translation and thereby modulate immunological function. We further describe approaches for

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OTHERS TRANSLATION FACTOR EIF5A IS ESSENTIAL FOR IFNΓ PRODUCTION AND CELL CYCLE REGULATION IN PRIMARY CD8+ T LYMPHOCYTES Article Open access 17 December 2022 DYNAMICS IN PROTEIN TRANSLATION

SUSTAINING T CELL PREPAREDNESS Article 06 July 2020 QUANTIFICATION OF TRANSLATION UNCOVERS THE FUNCTIONS OF THE ALTERNATIVE TRANSCRIPTOME Article 29 June 2020 REFERENCES * Bava, F.A. et al.

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(2012). Article  CAS  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS Supported by the Canadian Institutes for Health Research (I.T., and MOP 67211 to C.A.P.),

the Canada Research Chair program (C.A.P.), the Swedish Research Council (O.L.), the Swedish Cancer Society (O.L.) and the Wallenberg Academy Fellows program (O.L.). AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Department of Microbiology and Immunology, and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Canada Ciriaco A Piccirillo * FOCIS Centre of

Excellence and Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada Ciriaco A Piccirillo * Department of Oncology-Pathology, Cancer

Center Karolinska, Karolinska Institutet, Stockholm, Sweden Eva Bjur & Ola Larsson * Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill

University, Montréal, Canada Ivan Topisirovic * Department of Oncology, McGill University, Montréal, Canada Ivan Topisirovic * Department of Biochemistry, and Goodman Cancer Research Centre,

McGill University, Montreal, Canada Nahum Sonenberg Authors * Ciriaco A Piccirillo View author publications You can also search for this author inPubMed Google Scholar * Eva Bjur View

author publications You can also search for this author inPubMed Google Scholar * Ivan Topisirovic View author publications You can also search for this author inPubMed Google Scholar *

Nahum Sonenberg View author publications You can also search for this author inPubMed Google Scholar * Ola Larsson View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHORS Correspondence to Ciriaco A Piccirillo or Ola Larsson. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Piccirillo, C., Bjur, E., Topisirovic, I. _et al._ Translational control of immune responses: from

transcripts to translatomes. _Nat Immunol_ 15, 503–511 (2014). https://doi.org/10.1038/ni.2891 Download citation * Received: 23 February 2014 * Accepted: 08 April 2014 * Published: 19 May

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