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Access through your institution Buy or subscribe Long noncoding RNAs (lncRNAs) have been linked to the regulation of chromatin structure, gene expression and mRNA translation; however,
lncRNAs might serve other regulatory roles in the cell. In _Science_, Wang _et al_. describe a distinct regulatory mechanism for lnc-DC, a lncRNA that is expressed exclusively in
conventional dendritic cells (DCs) and is induced when monocytes differentiate into DCs. lnc-DC is required for the functional presentation of antigens and T cell–priming activities, as well
as for the expression of IL-12 by DCs. RNA-mediated interference of lnc-DC results in diminished expression of hundreds of DC-associated genes, which suggests its regulatory role might
differ from that of previously described lncRNAs. Instead, lnc-DC is associated with the transcription factor STAT3 in the cytoplasm. Loss of lnc-DC leads to less phosphorylation of STAT3 at
Tyr705, whereas ectopic expression of lnc-DC leads to more of this phosphorylation. lnc-DC seems to maintain activated STAT3 by protecting against dephosphorylation by the phosphatase
SHP-1, which indicates a unique function for lncRNAs. Whether lnc-DC-mediated regulation might also explain the distinct roles of STAT3 in various contexts deserves further investigation.
_Science_ 344, 310–313 (2014) This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print
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local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Laurie A.
Dempsey View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dempsey, L.
lncRNA for DCs. _Nat Immunol_ 15, 530 (2014). https://doi.org/10.1038/ni.2903 Download citation * Published: 19 May 2014 * Issue Date: June 2014 * DOI: https://doi.org/10.1038/ni.2903 SHARE
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