Fate ppar-titioning: ppar-γ 'instructs' alveolar macrophage development

Fate ppar-titioning: ppar-γ 'instructs' alveolar macrophage development

Play all audios:

Loading...

Alveolar macrophages derive from fetal monocytes that seed the lungs during late embryogenesis. The cytokine GM-CSF expressed in the developing lungs induces expression of the nuclear


receptor PPAR-γ, which in turn 'instructs' the differentiation of alveolar macrophage. Access through your institution Buy or subscribe This is a preview of subscription content,


access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn


more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS


OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ginhoux, F. & Jung, S. _Nat. Rev. Immunol._ 14, 392–404 (2014).


Article  CAS  PubMed  Google Scholar  * Epelman, S., Lavine, K.J. & Randolph, G.J. _Immunity_ 41, 21–35 (2014). Article  CAS  PubMed  PubMed Central  Google Scholar  * Schneider, C. et


al. _Nat. Immunol._ 15, 1026–1037 (2014). Article  CAS  PubMed  Google Scholar  * Schulz, C. et al. _Science_ 336, 86–90 (2012). Article  CAS  PubMed  Google Scholar  * Hoeffel, G. et al.


_J. Exp. Med._ 209, 1167–1181 (2012). CAS  PubMed Central  PubMed  Google Scholar  * Guilliams, M. et al. _J. Exp. Med._ 210, 1977–1992 (2013). Article  CAS  PubMed  PubMed Central  Google


Scholar  * Frame, J.M., McGrath, K.E. & Palis, J. _Blood Cells Mol. Dis._ 51, 220–225 (2013). Article  PubMed  Google Scholar  * Ginhoux, F. et al. _Science_ 330, 841–845 (2010). Article


  CAS  PubMed  PubMed Central  Google Scholar  * Epelman, S. et al. _Immunity_ 40, 91–104 (2014). Article  CAS  PubMed  PubMed Central  Google Scholar  * Gautier, E. et al. _Nat. Immunol._


13, 1118–1128 (2012). Article  CAS  PubMed  PubMed Central  Google Scholar  * Rosas, M. et al. _Science_ 344, 645–648 (2014). Article  CAS  PubMed  PubMed Central  Google Scholar  * Gautier,


E.L. et al. _J. Exp. Med._ 211, 1525–1531 (2014). Article  CAS  PubMed  PubMed Central  Google Scholar  * Okabe, Y. & Medzhitov, R. _Cell_ 157, 832–844 (2014). Article  CAS  PubMed 


PubMed Central  Google Scholar  * Kohyama, M. et al. _Nature_ 457, 318–321 (2009). Article  CAS  PubMed  Google Scholar  * Nakamura, A. et al. _J. Exp. Med._ 210, 2191–2204 (2013). Article 


CAS  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Florent Ginhoux is with the Singapore Immunology Network, Agency for Science,


Technology and Research, Immunos, Singapore., Florent Ginhoux Authors * Florent Ginhoux View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING


AUTHOR Correspondence to Florent Ginhoux. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT


THIS ARTICLE CITE THIS ARTICLE Ginhoux, F. Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development. _Nat Immunol_ 15, 1005–1007 (2014).


https://doi.org/10.1038/ni.3011 Download citation * Published: 20 October 2014 * Issue Date: November 2014 * DOI: https://doi.org/10.1038/ni.3011 SHARE THIS ARTICLE Anyone you share the


following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer


Nature SharedIt content-sharing initiative