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Alveolar macrophages derive from fetal monocytes that seed the lungs during late embryogenesis. The cytokine GM-CSF expressed in the developing lungs induces expression of the nuclear
receptor PPAR-γ, which in turn 'instructs' the differentiation of alveolar macrophage. Access through your institution Buy or subscribe This is a preview of subscription content,
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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ginhoux, F. & Jung, S. _Nat. Rev. Immunol._ 14, 392–404 (2014).
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CAS PubMed PubMed Central Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Florent Ginhoux is with the Singapore Immunology Network, Agency for Science,
Technology and Research, Immunos, Singapore., Florent Ginhoux Authors * Florent Ginhoux View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to Florent Ginhoux. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT
THIS ARTICLE CITE THIS ARTICLE Ginhoux, F. Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development. _Nat Immunol_ 15, 1005–1007 (2014).
https://doi.org/10.1038/ni.3011 Download citation * Published: 20 October 2014 * Issue Date: November 2014 * DOI: https://doi.org/10.1038/ni.3011 SHARE THIS ARTICLE Anyone you share the
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