Shaping the healthy repertoire

Shaping the healthy repertoire

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Access through your institution Buy or subscribe Although much is known about the generation and maintenance of memory T cells after infection, less is known about the fate and repertoire of such cells that arise naturally through life under homeostatic conditions. In the _Proceedings of the National Academy of Sciences_, Zhuang and colleagues use a novel fate-tracing system that allows T cells to be tracked over long time spans. As expected, mice 1.5 years of age have diminished thymic output but also have long-lived clones with greater representation of regulatory T cells than of conventional T cells. Repertoire analysis shows that the long-lived populations of conventional T cells and regulatory T cells share overlapping clonotypes that are consistent among different mice in similar housing conditions. The unambiguous enrichment for restricted regulatory T cell clonotypes suggests that they are being selected throughout the life of the host to maintain tolerance to self antigens and commensals. _Proc. Natl. Acad. Sci. USA_ (17 August 2016) doi:10.1073/pnas.1601634113 This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Zoltan Fehervari View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fehervari, Z. Shaping the healthy repertoire. _Nat Immunol_ 17, 1141 (2016). https://doi.org/10.1038/ni.3571 Download citation * Published: 20 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/ni.3571 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

Access through your institution Buy or subscribe Although much is known about the generation and maintenance of memory T cells after infection, less is known about the fate and repertoire of


such cells that arise naturally through life under homeostatic conditions. In the _Proceedings of the National Academy of Sciences_, Zhuang and colleagues use a novel fate-tracing system


that allows T cells to be tracked over long time spans. As expected, mice 1.5 years of age have diminished thymic output but also have long-lived clones with greater representation of


regulatory T cells than of conventional T cells. Repertoire analysis shows that the long-lived populations of conventional T cells and regulatory T cells share overlapping clonotypes that


are consistent among different mice in similar housing conditions. The unambiguous enrichment for restricted regulatory T cell clonotypes suggests that they are being selected throughout the


life of the host to maintain tolerance to self antigens and commensals. _Proc. Natl. Acad. Sci. USA_ (17 August 2016) doi:10.1073/pnas.1601634113 This is a preview of subscription content,


access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn


more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS


OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Zoltan Fehervari View author publications You can also search for this author


inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fehervari, Z. Shaping the healthy repertoire. _Nat Immunol_ 17, 1141 (2016).


https://doi.org/10.1038/ni.3571 Download citation * Published: 20 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/ni.3571 SHARE THIS ARTICLE Anyone you share the


following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer


Nature SharedIt content-sharing initiative