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Access through your institution Buy or subscribe Although much is known about the generation and maintenance of memory T cells after infection, less is known about the fate and repertoire of
such cells that arise naturally through life under homeostatic conditions. In the _Proceedings of the National Academy of Sciences_, Zhuang and colleagues use a novel fate-tracing system
that allows T cells to be tracked over long time spans. As expected, mice 1.5 years of age have diminished thymic output but also have long-lived clones with greater representation of
regulatory T cells than of conventional T cells. Repertoire analysis shows that the long-lived populations of conventional T cells and regulatory T cells share overlapping clonotypes that
are consistent among different mice in similar housing conditions. The unambiguous enrichment for restricted regulatory T cell clonotypes suggests that they are being selected throughout the
life of the host to maintain tolerance to self antigens and commensals. _Proc. Natl. Acad. Sci. USA_ (17 August 2016) doi:10.1073/pnas.1601634113 This is a preview of subscription content,
access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn
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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Zoltan Fehervari View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fehervari, Z. Shaping the healthy repertoire. _Nat Immunol_ 17, 1141 (2016).
https://doi.org/10.1038/ni.3571 Download citation * Published: 20 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/ni.3571 SHARE THIS ARTICLE Anyone you share the
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